Ruthenium(II) complexes of 1,12-diazaperyiene and their interactions with DNA
Ruthenium(II) complexes of 1,12-diazaperyiene and their interactions with DNA
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DOI：
10.1021/ic0485965
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发表时间：
2005-08-22
影响因子：
4.6
通讯作者：
Thummel, RP
中科院分区：
文献类型：
--
作者：
Chouai, A;Wicke, SE;Thummel, RP
合成了四种配体1，12-二氮杂萘（DAP）的配合物[Ru（bpy）（n）（DAP）（3-n）]（2+）和[Ru（DAP）（3）]（2+）。[Ru（DAP）（3）]（2+）配合物经X-射线衍射分析表明，配合物具有螺旋桨状结构，并具有明显的π-堆积相互作用.三种Ru（II）配合物显示出自洽的光电性质，在333-468 nm范围内具有类似的配体中心π-π（*）吸收，并且与DAP相关的MLCT带随着DAP配体的数目从1变化到3而强度增加并且能量降低。观察到与DAP嵌入DNA一致的减色性和粘度变化，并且对于混合配体络合物，测量的结合常数在1.4-1.6 x 10（6）M-1的范围内。此外，配合物[Ru（bpy）（2）（DAP）]（2+）在可见光照射下能光切割质粒DNA。
Four complexes of the ligand 1,12-diazaperylene (DAP) have been prepared, [Ru(bpy)(n)(DAP)(3-n)](2+) where n = 0-2 and [Ru(DAP)(3)](2+). The [Ru(DAP)(3)](2+) complex was characterized by X-ray analysis and was found to exhibit the expected propeller-like structure with significant intermolecular pi-stacking interactions. The three Ru(II) complexes showed self-consistent optoelectronic properties with similar ligand-centered pi-pi(*) absorptions in the range of 333-468 nm and MLCT bands associated with the DAP which increased in intensity and decreased in energy as the number of DAP ligands varied from 1 to 3. Hypochromicity and viscosity changes were observed that were consistent with DAP intercalation into DNA, and binding constants were measured in the range of 1.4-1.6 x 10(6) M-1 for the mixed ligand complexes. Furthermore, the complex [Ru(bpy)(2)(DAP)](2+) was found to photocleave plasmid DNA upon irradiation with visible light.