Age-related trends in the timeliness and prediction of medical visits, hospitalizations and deaths due to pneumonia and influenza, British Columbia, Canada, 1998-2004
Age-related trends in the timeliness and prediction of medical visits, hospitalizations and deaths due to pneumonia and influenza, British Columbia, Canada, 1998-2004
复制标题
DOI：
10.1016/j.vaccine.2007.11.090
复制
发表时间：
2008-03-04
期刊：
影响因子：
5.5
通讯作者：
Brownstein, J. S.
中科院分区：
文献类型：
--
作者：
Sebastian, R.;Skowronski, D. M.;Brownstein, J. S.
北美的流感免疫规划主要旨在为接种疫苗的严重流感后果风险最高的个人提供直接益处。一些证据表明，某些年龄组的免疫接种也可能使脆弱人群间接受益。我们的目标是确定与季节性流感活动最早相关的年龄组，以及谁可能在人口水平上产生最大的间接影响。我们使用加拿大不列颠哥伦比亚省的行政数据集，研究了流感就诊与肺炎Et流感（P&I）引起的全人群住院/死亡率之间基于年龄的关联。根据该研究年度某一周观察到的最高发病率，确定了每个年龄组的高峰周。高峰周的平均发病率是每个年龄组在研究期间的平均值。及时性(T)定义为流感就诊首次高峰与全人群保赔住院/死亡之间的平均天数差。应用泊松回归计算预测（Pr）作为流感就诊解释的P&I偏差的平均比例。T和Pr是按年龄组得出的，乘积（T × Pr）被用作按年龄组对流感潜在间接影响进行排序的汇总度量。幼儿（0-23个月）和老年人（65岁）的伤损住院率最高。孩子们
The influenza immunization program in North America has been primarily designed to provide direct benefit to vaccinated individuals at highest risk of serious influenza outcomes. Some evidence suggests that immunization of certain age groups may also extend indirect protective benefit to vulnerable populations. Our goal was to identify age groups associated earliest with seasonal influenza activity and who may have the greatest indirect impact at the population Level.. We examined age-based associations between influenza medical visits and population-wide hospitalization / mortality due to pneumonia Et influenza (P&I) using administrative datasets in British Columbia, Canada. A peak week was identified for each age group based on the highest rates observed in a given week for that study year. Mean rates at the peak week were averaged over the study years per age group. Timeliness (T) was defined as the mean difference in days between the first peak in influenza medical visits and population-wide P&I hospitalizations/ deaths. Poisson regression was applied to calculate prediction (Pr) as the average proportion of deviance in P&I explained by influenza medical visits. T and Pr were derived by age group, and the product (T x Pr) was used as a summary measure to rank potential indirect effects of influenza by age group. Young children (0-23 months) and the elderly ( 65 years) had the highest peak rates of P&I hospitalization. Children