BMI changes in adolescents treated with bupropion SR for smoking cessation.
BMI changes in adolescents treated with bupropion SR for smoking cessation.
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DOI：
10.1002/oby.21360
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Leischow SJ
中科院分区：
文献类型：
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作者：
Floden L;Taren DL;Muramoto ML;Leischow SJ
Adolescent overweight and obesity and smoking continue to be very important health challenges because of their lasting affects on overall health. Weight gain after smoking cessation is a barrier to quitting as well as a consequence of health status. This study reports changes in the body mass index (BMI) z-scores of adolescent smokers participating in a dose-ranging clinical trial of bupropion SR (150mg/day and 300mg/day) for smoking cessation. A total of N=296 adolescent smokers (placebo n=100, 150mg/day n=101, 300mg/day n=95) with a BMI z-score of 0.5 (sd: 1.4), 0.5 (sd: 1.3), and 0.5 (sd: 1.2) in the placebo, 150 mg/day and 300 mg/day groups, respectively, were followed for six months. Adolescents in the 300mg/day group had a significant reduction in BMI z-score at 6 week post quit (β = −0.16, CI= (−0.29, −0.04), p-value = 0.01). This result was not sustained at the six-month follow up. A reduction in BMI z-score during smoking cessation with bupropion has important implications for the future of adolescent smoking cessation. These results are particularly relevant for adolescents who are either overweight or obese, or have reservations about quitting for fear of gaining weight or BMI.
