Genetic influences on muscle strength, lean body mass, and bone mineral density: A twin study
Genetic influences on muscle strength, lean body mass, and bone mineral density: A twin study
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DOI：
10.1359/jbmr.1997.12.12.2076
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发表时间：
1997-12-01
影响因子：
6.2
通讯作者：
Spector, TD
中科院分区：
文献类型：
--
作者：
Arden, NK;Spector, TD
瘦体重和肌肉力量都与骨矿密度(BMD)有关，众所周知，骨密度受强烈的基因控制。在这项经典的双胞胎研究中，我们研究了肌肉力量和瘦身质量的遗传成分的大小以及它们对BMD的遗传成分的解释程度，总共检查了706名绝经后妇女；227对同卵双胞胎(MZ)和126对异卵双胞胎(DZ)，用手扶握把球测量握力，用动态腿部加强器测量腿部力量；用双能X射线吸收计量仪测量多个部位的张力机、瘦体重和BMD；BMD与腿部伸肌力量(r=0.16-0.26)和握力(i=0.12-0.21)相关，瘦体重与所有部位的BMD显著相关(i=0.20-0.39)，所有这三个肌肉变量都具有中等遗传力，遗传力估计为瘦体重0.52，腿伸肌力0.46，握力0.30(均p<；(0.05)，调整瘦体重和肌肉力量后，BMD的遗传成分没有显著降低，只有不到20%的BMD遗传有效性由肌肉变量解释，这些数据表明，这三个肌肉变量的遗传成分具有适度的遗传成分，暗示了临床干预和生活方式改变的可能性，肌肉体积和力量的遗传成分对BMD的遗传成分的影响很小，证实了研究骨骼特异基因的理论基础。
Lean body mass and muscle strength are both associated with bone mineral density (BMD), which is known to be under strong genetic control. In this classical twin study, we examine the size of the genetic component of both muscle strength and lean body mass and to what degree they account for the genetic Component of BMD, In all, 706 postmenopausal women were examined; 227 pairs of monozygous (MZ) twins and 126 pairs of dizygous (DZ) twins, Grip strength was measured using a hand-help grip bulb and leg strength using a dynamic leg er;tensor power rig, Lean body mass and BMD at multiple sites were measured by dual-energy X-ray absorptiometry; BMD cell-elated with both leg extensor strength (r = 0.16-0.26) and grip strength (I = 0.12-0.21), Lean mass was significantly correlated with BMD at all sites (I = 0.20-0.39), All three muscle variables have a moderate genetic component with heritability estimates of 0.52 for lean body mass, 0.46 for leg extensor strength, and 0.30 for grip strength (all p < 0.05), The genetic component of BMD was not significantly reduced after-adjusting for lean mass and muscle strength, with less than 20% of the genetic valiance of BMD explained by the muscle variables, In conclusion, these data suggest, that the three muscle variables have a modest genetic component, suggesting the potential for clinical intervention and lifestyle modifications, The genetic component to muscle bulk and strength accounts for little of the genetic component to BMD, confirming the rationale for research into bone-specific genes.