The interplay between HIV and COVID-19: summary of the data and responses to date.
The interplay between HIV and COVID-19: summary of the data and responses to date.
复制标题
DOI：
10.1097/coh.0000000000000659
复制
发表时间：
2021-01
影响因子：
4.1
通讯作者：
Gandhi M
中科院分区：
文献类型：
--
作者：
Brown LB;Spinelli MA;Gandhi M
我们研究了艾滋病毒和COVID-19疫情之间的相互作用，包括艾滋病毒对COVID-19易感性和严重疾病的影响，COVID-19疫情对艾滋病毒预防和治疗的影响，以及艾滋病毒疫情对应对COVID-19的影响。迄今为止的证据并不表明艾滋病毒感染者（PLWH）对SARS-CoV-2感染的易感性明显更高，健康和合并症的社会决定因素的差异可能具有更大的影响。大多数文献并不支持欧洲和美国的PLWH患严重疾病的风险较高，尽管南非的一项大型基于人群的研究报告了COVID-19导致的死亡率较高。PLWH中与COVID-19疾病严重程度相关的合并症发生率较高是一个迫切关注的问题。COVID-19导致艾滋病毒预防服务和艾滋病毒检测的可及性下降，艾滋病毒治疗的可及性和病毒学抑制恶化，这可能导致艾滋病毒流行控制恶化。COVID-19正在威胁抗击艾滋病毒流行病的成果，包括美国终止艾滋病毒流行病的目标。这两种全球流行病的持续碰撞将继续需要研究和干预措施，以减轻COVID-19对全球艾滋病毒工作的影响。
We examine the interplay between the HIV and COVID-19 epidemics, including the impact of HIV on COVID-19 susceptibility and severe disease, the effect of the COVID-19 epidemic on HIV prevention and treatment, and the influence of the HIV epidemic on responses to COVID-19. Evidence to date does not suggest that people living with HIV (PLWH) have a markedly higher susceptibility to SARS-CoV-2 infection, with disparities in the social determinants of health and comorbidities likely having a greater influence. The majority of literature has not supported a higher risk for severe disease among PLWH in Europe and the United States, although a large, population-based study in South Africa reported a higher rate of death due to COVID-19. Higher rates of comorbidities associated with COVID-19 disease severity among PLWH is an urgent concern. COVID-19 is leading to decreased access to HIV prevention services and HIV testing, and worsening HIV treatment access and virologic suppression, which could lead to worsening HIV epidemic control. COVID-19 is threatening gains against the HIV epidemic, including the U.S. Ending the HIV Epidemic goals. The ongoing collision of these two global pandemics will continue to need both study and interventions to mitigate the effects of COVID-19 on HIV efforts worldwide.