Radiation-Association Hypertension in Patients Undergoing Treatment for Prostate Cancer.
Radiation-Association Hypertension in Patients Undergoing Treatment for Prostate Cancer.
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DOI：
10.1017/s1460396919000670
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发表时间：
2020-06
影响因子：
0.4
通讯作者：
Mattes MD
中科院分区：
文献类型：
--
作者：
Farrugia MK;Mattes MD
前列腺放射治疗的患者在临床上被观察到血压升高。因此，我们寻求进一步消除这一现象。检查了2014年至2017年期间接受前列腺癌放射治疗的76名患者的图表。血压（BP）读数在初始咨询时获得，治疗访视，随后的后续任命。为了描述这种效应，我们将放射相关性高血压（RAH）定义为收缩压升高≥15 mmHg，舒张压升高≥ 10 mmHg或平均动脉压升高≥ 5 mmHg。在该队列中，36例患者发生RAH，其中75%在治疗期间发生RAH，25%在治疗后访视时发生RAH。三分之二的患者在治疗后访视期间仍有高血压，27%的患者接受了额外的抗高血压药物。新辅助/同期雄激素剥夺治疗与RAH之间无相关性。大量接受前列腺放疗的患者发生RAH，一些患者需要额外的药物治疗。
Patients undergoing prostate radiation therapy were observed to have elevated blood pressures in clinic. Therefore, we sought to further characterise this phenomenon. The charts of 76 patients who received radiotherapy for prostate cancer between 2014 and 2017 were examined. Blood pressure (BP) readings were obtained at initial consultation, on treatment visits, and subsequent follow-up appointments. To describe this effect, we defined radiation-associated hypertension (RAH) as an increase ≥15 mmHg systolic BP, 10 mmHg diastolic BP, or 5 mmHg mean arterial pressure. Within this cohort, 36 patients developed RAH, with 75% developing RAH while on treatment, and 25% developing RAH at post-treatment visits. Two-thirds of patients remained hypertensive during post-treatment visits, and 27% were prescribed additional anti-hypertensives. There was no association between neoadjuvant/concurrent androgen deprivation therapy and RAH. A significant number of patients undergoing prostate radiotherapy developed RAH, necessitating additional medication in some.
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影响因子：
45.3
作者：
Zagars, GK;Ballo, MT;Strom, SS
通讯作者：
Strom, SS
影响因子：
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作者：
Goyal, Manish;Shukla, Pragya;Bhatt, Madan Lal
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Bhatt, Madan Lal
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作者：
MILUTINOVIC, J;DARCY, M;THOMPSON, KA
通讯作者：
THOMPSON, KA