Modulation of human immune and inflammatory responses by dietary fatty acids
Modulation of human immune and inflammatory responses by dietary fatty acids
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DOI：
10.1016/s0899-9007(01)00576-7
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发表时间：
2001-07-01
期刊：
影响因子：
4.4
通讯作者：
Kelley, DS
中科院分区：
文献类型：
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作者：
Kelley, DS
本文综述了膳食脂肪的含量和组成对人体免疫和炎症反应的影响。脂肪摄入量的减少增强了免疫反应的几个指标，包括淋巴细胞增殖，自然杀伤细胞活性，细胞因子的产生和迟发型超敏反应。当总脂肪摄入量保持不变时，健康志愿者摄入亚油酸（18：2 ω-6）或花生四烯酸（20：4 ω-6）的增加不会抑制许多免疫反应指标，但会增加炎症性类花生酸（前列腺素E2和白三烯B4）的产生。补充人类饮食中的ω-3脂肪酸减少了中性粒细胞，单核细胞和淋巴细胞功能的几个方面，包括炎症介质的产生。大多数研究表明，这些功能的减少，最低1.2克/天的补充与二十碳五烯酸和二十二碳六烯酸6周。然而，其他研究伴随补充205 mg/d维生素E没有发现免疫细胞功能的抑制，即使补充这些脂肪酸的量更大，持续时间更长。一项研究报告说，补充二十二碳六烯酸选择性地抑制炎症反应，而不抑制T细胞和B细胞功能。尽管存在一些差异，但鱼油已成功用于管理几种炎症和自身免疫性疾病。使用鱼油治疗这些疾病的潜力是巨大的，尽管需要进一步研究以确定0-3脂肪酸的安全和适当摄入水平。
I review the effects of the amount and composition Of dietary fat on indices of human immune and inflammatory responses. A reduction in the amount of fat intake enhanced several indices of immune response, including lymphocyte proliferation, natural-killer-cell activity, cytokine production, and delayed-type hypersensitivity. When total fat intake was held constant, an increase in the intake of linoleic acid (18:2 omega -6) or arachidonic acid (20:4 omega -6) by healthy human volunteers did not inhibit many indices of immune response tested but did increase the production of inflammatory eicosanoids (prostaglandin E2 and leukotriene B4). Supplementation of human diets with omega -3 fatty acids reduced several aspects of neutrophil, monocyte, and lymphocyte functions, including the production of inflammatory mediators. Most of the studies have indicated reductions in these functions, with a minimum of 1.2 g/d of supplementation with eicosapentaenoic acid and docosahexaenoic acid for 6 wk. However, other studies concomitantly supplementing with 205 mg/d of vitamin E did not find inhibition of immune-cell functions, even with larger amounts and longer durations of supplementation with these fatty acids. One study reported that supplementation with docosahexaenoic acid selectively inhibits inflammatory responses without inhibiting T- and B-cell functions. Despite some discrepancies, fish oils have been used successfully in the management of several inflammatory and autoimmune diseases. The potential for the use of fish oils in the management of these diseases is tremendous, even though further studies are needed to establish safe and adequate intake levels of 0-3 fatty acids.