Pregnancy-associated malaria affects toll-like receptor ligand-induced cytokine responses in cord blood
Pregnancy-associated malaria affects toll-like receptor ligand-induced cytokine responses in cord blood
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DOI：
10.1086/591057
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发表时间：
2008-09-15
影响因子：
6.4
通讯作者：
Yazdanbakhsh, Maria
中科院分区：
文献类型：
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作者：
Adegnika, Ayola A.;Koehler, Carsten;Yazdanbakhsh, Maria
背景已知妊娠相关疟疾会改变胎儿免疫力。大多数以前的研究都是横截面的性质，并集中在子宫内获得性免疫反应的启动。在这种情况下，胎盘感染恶性疟原虫的时间和/或持续时间的影响是未知的，先天免疫反应的变化还没有被广泛研究。在恶性疟原虫感染流行的加蓬，对怀孕妇女从第二孕期到分娩期间每月进行一次临床和寄生虫学检查。获得性恶性疟原虫感染母亲所生新生儿的细胞
Background. Pregnancy-associated malaria is known to modify fetal immunity. Most previous studies have been cross-sectional in nature and have focused on the priming of acquired immune responses in utero. In this context, the influence of the timing and/or duration of placental infection with Plasmodium falciparum are unknown, and changes to innate immune responses have not been studied extensively.Methods. Pregnant women in Gabon, where P. falciparum infection is endemic, were followed up through monthly clinical and parasitological examinations from the second trimester to delivery. Cells of neonates born to mothers who had acquired P. falciparum infection