Devic's neuromyelitis optica: clinical features and prognostic factors
Devic's neuromyelitis optica: clinical features and prognostic factors
复制标题
DOI：
10.1007/s10072-004-0342-0
复制
发表时间：
2004-11-01
影响因子：
3.3
通讯作者：
Ghezzi, A
中科院分区：
文献类型：
--
作者：
Bergamaschi, R;Ghezzi, A
Devic的视神经肌炎（NMO）发作的特点是视神经炎（ON）和横肌炎（TM），无论是同时或单独。此后，疾病的过程可以是双相的（没有其他攻击）或复发（ON和TM序列，没有其他神经系统参与）。复发性病程的风险与性别、发病时年龄较大、发病后运动功能障碍较轻、首次和第二次发作间隔时间有关。在复发过程中出现不利进展（严重残疾或死亡）的风险主要与疾病头两年的高复发率有关。总之，复发性NMO患者往往预后不良，需要更有效的免疫抑制治疗。
Devic's neuromyelitis optica (NMO) onset is characterized by optic neuritis (ON) and transverse myelitis (TM), either simultaneously or in isolation. Thereafter, the course of the disease can be monophasic (no other attack) or relapsing (sequences of ON and TM, no other neurological system involved). The risk of having a relapsing course is related to gender, older age at onset, less severe motor impairment after the myelitic onset, interval length between first and second attack. The risk of an unfavourable evolution (severe disability or death) during a relapsing course is mainly related to high relapse rate during the first two years of the disease. In summary, relapsing NMO patients tend to have a poor prognosis, requiring more effective immunosuppressive treatments.