The role of uncoupling proteins in pathophysiological states
The role of uncoupling proteins in pathophysiological states
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DOI：
10.1016/s0006-291x(02)00355-8
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发表时间：
2002-05-17
影响因子：
3.1
通讯作者：
López-Soriano, FJ
中科院分区：
文献类型：
--
作者：
Argilés, JM;Busquets, S;López-Soriano, FJ
直到最近，解偶联蛋白-1 (UCP1)，仅存在于棕色脂肪组织（BAT）中，被认为是唯一的线粒体载体蛋白，通过消散呼吸过程中产生的质子梯度穿过线粒体内膜，从而使呼吸从ATP合成中解偶联，从而刺激产热。和脑线粒体载体蛋白-1 （BMCP-1）已在哺乳动物组织中被描述。本综述探讨了这些蛋白在不同病理条件下的可能作用，包括能量平衡的改变，如肥胖或恶病质。总之，UCP家族的出现改变了生物能量学的方法，并强调了在不同病理生理条件下解耦呼吸的重要性。对哺乳动物组织中UCP家族新成员的广泛定性和定量表征将有助于更好地理解产热和能量代谢的分子和调节机制。在这一点上，我们希望本综述中提出的知识不仅会激发关于UCP家族在疾病中的作用的辩论，而且还会导致有益于人类健康的应用。(C) 2002 Elsevier Science （USA）。版权所有。
Until very recently, the uncoupling protein-1 (UCP1), present only in brown adipose tissue (BAT), was considered to be the only mitochondrial carrier protein that stimulated heat production by dissipating the proton gradient generated during respiration across the inner mitochondrial membrane and therefore uncoupling respiration from ATP synthesis, Recently, new uncoupling proteins, UCP2, UCP3, and UCP4, and brain mitochondrial carrier protein-1 (BMCP-1) have been described in mammalian tissues. The present review deals with the possible role of these proteins in different pathological conditions involving alterations in energy balance such as obesity or cachexia. In conclusion, the emergence of the UCP family has altered the approaches to bioenergetics and stressed the importance of uncoupling respiration in different pathophysiological conditions. An extensive qualitative and quantitative characterization of the new members of the UCP family in mammalian tissues will allow a better understanding of the molecular and regulatory mechanisms of thermogenesis and energy metabolism. At this point, we hope that the knowledge presented in the present review will not only stimulate a debate about the role of the UCP family in disease but also lead to applications beneficial for human health. (C) 2002 Elsevier Science (USA). All rights reserved.