Immune phenotypes predict survival in patients with glioblastoma multiforme.
Immune phenotypes predict survival in patients with glioblastoma multiforme.
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DOI：
10.1186/s13045-016-0272-3
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发表时间：
2016-09-01
影响因子：
28.5
通讯作者：
Schneider EM
中科院分区：
文献类型：
--
作者：
Mostafa H;Pala A;Högel J;Hlavac M;Dietrich E;Westhoff MA;Nonnenmacher L;Burster T;Georgieff M;Wirtz CR;Schneider EM
多形性胶质母细胞瘤（GBM）是一种常见的原发性恶性脑肿瘤，很少扩散到中枢神经系统以外，预后非常差。本研究旨在分析个体GBM患者的免疫控制情况。在诊断时分别用流式细胞术和ELISA检测GBM患者的免疫表型和血浆生物标志物。使用描述性统计，我们发现免疫异常在个体患者中是不同的。明确的标记谱与生存高度相关。在GBM患者中活化NK细胞与改善生存率之间存在显著的关系，而在病程不良且生存期很短的患者中CD39和IL-10升高。递归分配分析（RPA）和Cox比例风险模型证实了CD8细胞的绝对数量和CD39细胞的低数量与更好的生存率之间的相关性。免疫系统的明确改变可能指导GBM患者的病程，可能对纵向研究具有预后价值或可用于免疫干预。本文的在线版本（doi:10.1186/s13045-016-0272-3）包含补充材料，可供授权用户使用。
Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond the central nervous system and has a very bad prognosis. The current study aimed at the analysis of immunological control in individual patients with GBM. Immune phenotypes and plasma biomarkers of GBM patients were determined at the time of diagnosis using flow cytometry and ELISA, respectively. Using descriptive statistics, we found that immune anomalies were distinct in individual patients. Defined marker profiles proved highly relevant for survival. A remarkable relation between activated NK cells and improved survival in GBM patients was in contrast to increased CD39 and IL-10 in patients with a detrimental course and very short survival. Recursive partitioning analysis (RPA) and Cox proportional hazards models substantiated the relevance of absolute numbers of CD8 cells and low numbers of CD39 cells for better survival. Defined alterations of the immune system may guide the course of disease in patients with GBM and may be prognostically valuable for longitudinal studies or can be applied for immune intervention. The online version of this article (doi:10.1186/s13045-016-0272-3) contains supplementary material, which is available to authorized users.
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