Cachexia criteria in chronic illness associated with acute weight loss in patients with stroke
Cachexia criteria in chronic illness associated with acute weight loss in patients with stroke
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中风患者急性体重减轻相关慢性病恶病质标准
DOI：
10.1016/j.nut.2021.111562
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发表时间：
2022
期刊：
影响因子：
4.4
通讯作者：
Shomoto Koji
中科院分区：
文献类型：
--
作者：
Yamamoto Miho;Nozoe Masafumi;Masuya Rio;Yoshida Yosuke;Kubo Hiroki;Shimada Shinichi;Shomoto Koji
目的卒中后体重减轻与不良预后相关。然而，中风急性期体重减轻的原因尚未完全了解。本研究的目的是探讨急性中风患者的急性体重变化和恶病质标准之间的关系。MethodsIn this prospective-cohort study，我们评估了患者在住院期间的体重变化，并研究了急性中风患者出院时的5个恶病质标准（肌力、疲劳、厌食、骨骼肌质量和生化异常）。如果符合≥3项恶病质标准，则将患者定义为恶病质。进行多变量分析，以探讨体重变化和恶病质criteria.ResultsA共155例急性脑卒中患者参加了这项研究，30例（19%）被发现有体重减轻（≥5%体重减轻）之间的关系。单因素回归分析发现恶病质标准与体重变化显著相关（β = -0.338;P< 0.001）。校正能量摄入、年龄、性别、入院时体重指数、国立卫生研究院卒中量表评分、炎症性疾病、住院时间、卧床时间和吞咽功能后的多变量分析显示，恶病质标准与体重变化显著相关结论脑卒中患者恶病质标准与急性体重减轻独立相关。
ObjectivesWeight loss after a stroke is associated with poor outcomes. However, the causes of weight loss in the acute phase of a stroke are not fully understood. The purpose of this study was to investigate the relationship between acute weight changes and cachexia criteria in patients with an acute stroke.MethodsIn this prospective-cohort study, we assessed patients’ body weight change during hospitalization, and investigated the five cachexia criteria (muscle strength, fatigue, anorexia, skeletal muscle mass, and abnormal biochemistry) at time of discharge in patients with an acute stroke. A patient was defined as being cachectic if ≥3 cachexia criteria were met. A multivariate analysis was performed to investigate the relationship between weight changes and cachexia criteria.ResultsA total of 155 patients with an acute stroke were enrolled in this study, and 30 patients (19%) were found to have weight loss (≥5% weight loss). A univariate regression analysis found that the cachexia criteria were significantly associated with weight changes (β = –0.338;P< 0.001). The multivariate analyses after adjusting for energy intake, age, sex, body mass index at time of admission, National Institutes of Health stroke scale score, inflammatory disease, length of hospital stay, length of bed rest, and swallowing function showed that the cachexia criteria were significantly associated with weight changes (β = –0.154;P= 0.043).ConclusionsThe cachexia criteria were independently associated with acute weight loss in patients with a stroke.