Clinical Features and Outcomes of Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Infants and Toddlers
Clinical Features and Outcomes of Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Infants and Toddlers
复制标题
DOI：
10.1016/j.pediatrneurol.2021.02.009
复制
发表时间：
2021-04-07
影响因子：
3.8
通讯作者：
Fang, Fang
中科院分区：
文献类型：
--
作者：
Ren, Changhong;Zhang, Weihua;Fang, Fang
目的：我们描述了抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎的婴儿和幼儿的临床特点和结果。方法：这是一个单中心的回顾性研究。招募符合抗NMDAR脑炎诊断标准的婴儿和幼儿进行研究。临床特征，治疗和长期outcome.Results的数据收集：共41例患者（年龄范围：6至34个月，中位年龄：23个月，女性：19）参加了这项研究。19例（46%）患者表现出典型的抗NMDAR脑炎，而22例（54%）患者在病毒性脑炎后表现出抗NMDAR脑炎。运动障碍、发育退化、行为异常的发生率分别为10 0%、90%、90%。所有患者均接受一线治疗，其中只有17%接受二线免疫治疗。两名病人死于这种疾病，但没有一人复发。在长期随访（超过一年）时，35例患者中有20例（57%）表现出令人满意的结果（改良的兰金量表
Objective: We describe the clinical features and outcomes of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in infants and toddlers.Methods: This was a single-center retrospective study. Infants and toddlers who met the diagnostic criteria for anti-NMDAR encephalitis were recruited for the study. Data on clinical features, treatment, and long-term outcomes were collected retrospectively.Results: A total of 41 patients (age range: six to 34 months; median age: 23 months; female: 19) were enrolled in this study. Nineteen (46%) patients exhibited classical anti-NMDAR encephalitis, whereas 22 (54%) patients exhibited anti-NMDAR encephalitis after viral encephalitis. There was a high presentation of movement disorders (10 0%), developmental regression (90%), abnormal behaviors (90%). All patients were administered first-line therapy, with only 17% of them being administered second-line immunotherapy. Two patients succumbed to the disease, whereas none of them relapsed. At the long-term follow-up (more than one year), 20 of 35 (57%) exhibited satisfactory outcomes (modified Rankin Scale