Revolutionizing Prosthetics—Phase 3
Revolutionizing Prosthetics—Phase 3
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革新假肢——第三阶段
DOI：
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发表时间：
2013
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通讯作者：
Brock Andrew Wester
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作者：
Alan D. Ravitz;Michael P. Mcloughlin;J. Beaty;F. Tenore;Matthew S. Johannes;Scott A. Swetz;John B. Helder;Kapil D. Katyal;Matthew P. Para;K. Fischer;T. Gion;Brock Andrew Wester
366 引言 纵观历史，战场上肢体和/或运动功能的丧失一直是假肢领域技术进步的主要驱动力。除了普通公众中也有类似损伤和状况的个体外，近期军事行动造成截肢或脊髓损伤的个体的存在，强调了加快恢复丧失功能的迫切需要。 2006 年初，APL 获得了一份合同，启动“革命性假肢 2009”计划的第一阶段，这是一项历时数年、耗资数百万美元的项目，旨在开发先进的上肢假肢，即模块化假肢 (MPL)。该项目的目标是开发一种先进的肢体，让假肢佩戴者能够扣衬衫扣子、调收音机、感受亲人手的温暖；这样的肢体甚至可以为战士提供重返现役的机会。目前正处于革命性假肢的第三阶段，APL 正在领导国防高级研究计划局努力为那些无法控制自己手臂的人提供上肢功能，例如截肢者和患有严重脊髓损伤或神经退行性疾病（例如肌萎缩侧索硬化症）的人。该计划的第 3 阶段重点关注临床活动，包括成熟 MPL 的稳健性、提交监管文件、设计和执行临床前和临床活动以及推进皮质植入技术。第三阶段的第三年的初步临床活动涉及一位四肢瘫痪的受试者，使用脑机接口来控制 MPL。随着项目团队在第三阶段准备另外四名受试者，对该受试者的进一步试验仍在继续。革命性假肢——第三阶段
366 INTRODUCTION Throughout history, the battlefield loss of limbs and/ or motor function has been the major driving force for technological progress in the field of prosthetics. The existence of individuals with amputations or spinal cord injuries resulting from recent military operations, in addition to individuals in the general public with similar injuries and conditions, emphasizes the urgent need to accelerate the progress toward restoring lost function. n early 2006, APL was awarded a contract to start the first phase of the Revolutionizing Prosthetics 2009 program, a multiyear, multimillion-dollar effort to develop an advanced upper-extremity prosthetic limb, the Modular Prosthetic Limb (MPL). This program’s goal is to develop an advanced limb that would allow a prosthetic wearer to button a shirt, tune a radio, and feel the warmth of a loved one’s hand; such a limb might even provide the warfighter with the opportunity to return to active duty. Currently in the third phase of Revolutionizing Prosthetics, APL is leading the Defense Advanced Research Projects Agency’s effort to provide upperextremity functionality to people who have no ability to control their native arms, such as amputees and those with high spinal cord injury or neurodegenerative diseases such as amyotrophic lateral sclerosis. Phase 3 of the program involves significant focus on clinical activities including maturing the MPL’s robustness, submitting regulatory filings, designing and executing preclinical and clinical activities, and advancing cortical implant technology. Initial clinical activities during this third year of Phase 3 have involved a subject with tetraplegia using a brain computer interface to control the MPL. Further trials with this subject continue as the program team prepares for four additional subjects during Phase 3. Revolutionizing Prosthetics—Phase 3