TASTE RECEPTOR-CELLS ARISE FROM LOCAL EPITHELIUM, NOT NEUROGENIC ECTODERM
TASTE RECEPTOR-CELLS ARISE FROM LOCAL EPITHELIUM, NOT NEUROGENIC ECTODERM
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DOI：
10.1073/pnas.92.6.1916
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发表时间：
1995-03-14
影响因子：
11.1
通讯作者：
TAN, SS
中科院分区：
文献类型：
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作者：
STONE, LM;FINGER, TE;TAN, SS
除味蕾细胞外，所有感觉受体细胞和神经元均显示起源于神经源性外胚层（即，神经管、神经嵴或外胚层基板）。然而，对味蕾的描述性研究表明，它们可能来自局部上皮。为了确定味觉感受器细胞是否起源于神经源性外胚层或局部上皮，检查了X染色体失活镶嵌小鼠的舌头。该分析的结果表明，味蕾细胞和它们周围的上皮在嵌合标记方面总是匹配的。这表明味觉细胞和上皮细胞来自共同的祖先，味觉受体细胞起源于局部组织成分。由于味蕾广泛分布于口咽部，它们位于来源于外胚层和内胚层的上皮中。因此，味觉感受器细胞可以在来自两个不同胚层的组织中被诱导。因此，就起源组织而言，味觉感受器细胞不同于其他具有神经元特征的细胞。
Except for taste bud cells, all sensory receptor cells and neurons have been shown to originate from neurogenic ectoderm (i.e., neural tube, neural crest, or ectodermal placodes). Descriptive studies on taste buds indicate that they, however, may arise from local epithelium. To determine whether taste receptor cells originate from neurogenic ectoderm or from local epithelium, the tongues of X chromosome-inactivation mosaic mice were examined. Results of this analysis show that taste bud cells and their surrounding epithelium always match in terms of the mosaic marker. This suggests that taste cells and epithelial cells arise from a common progenitor and that taste receptor cells originate from local tissue elements. Since taste buds are widespread in the oropharynx, they lie in epithelium derived from both ectoderm and endoderm. Therefore, taste receptor cells can be induced in tissue from two different germ layers. Thus in terms of tissues of origin, taste receptor cells are unlike other cells with neuronal characteristics.