Penalized maximum likelihood reconstruction for improved microcalcification detection in breast tomosynthesis.
Penalized maximum likelihood reconstruction for improved microcalcification detection in breast tomosynthesis.
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DOI：
10.1109/tmi.2010.2089694
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发表时间：
2011-04
影响因子：
10.6
通讯作者：
Glick SJ
中科院分区：
文献类型：
--
作者：
Das M;Gifford HC;O'Connor JM;Glick SJ
我们研究了迭代惩罚最大似然 (PML) 重建方法的应用，以提高数字乳腺断层合成 (DBT) 中微钙化 (MC) 的可检测性。通过人类观察者和 2D 图像切片进行局部接收者操作特性 (LROC) 心理物理学研究，以评估该重建方法的性能，并将其性能与常用的 Feldkamp FBP 算法进行比较。 DBT 投影是使用严格的计算机模拟生成的，其中包括噪声和探测器模糊的精确建模。在 5 厘米厚的压缩乳房中测试了 0.7、1.0 和 1.5 mGy 的采集剂量水平。定义的任务是定位和检测由七个 MC 组成的 MC 集群。单个MC直径为150μm。来自实际乳房切除标本的 CT 图像的受压乳房模型为检测任务提供了真实的背景结构。对于重建方法和采集剂量的每种组合，四名观察者每人读取 98 张测试图像。所有观察者使用 PML 图像都比使用 FBP 图像表现得更好。当采集剂量为 0.7 mGy 时，PML 和 FBP 算法的 LROC 曲线下平均面积 (AL) 分别为 0.69 和 0.43。对于 1.0 mGy 剂量，AL 值分别为 0.93 (PML) 和 0.7 (FBP)，而 1.5 mGy 剂量则导致 PML 和 FBP 算法的面积分别为 1.0 和 0.9。应用于各个观察区域的二维方差分析显示，所有三个剂量水平的重建策略之间存在统计显着差异（显着性水平为 0.05）。对于任何剂量水平，观察者的表现都没有显着差异。
We examined the application of an iterative penalized maximum likelihood (PML) reconstruction method for improved detectability of microcalcifications (MCs) in digital breast tomosynthesis (DBT). Localized receiver operating characteristic (LROC) psychophysical studies with human observers and 2D image slices were conducted to evaluate the performance of this reconstruction method and to compare its performance against the commonly used Feldkamp FBP algorithm. DBT projections were generated using rigorous computer simulations that included accurate modeling of the noise and detector blur. Acquisition dose levels of 0.7, 1.0 and 1.5 mGy in a 5-cm-thick compressed breast were tested. The defined task was to localize and detect MC clusters consisting of seven MCs. The individual MC diameter was 150 μm. Compressed-breast phantoms derived from CT images of actual mastectomy specimens provided realistic background structures for the detection task. Four observers each read 98 test images for each combination of reconstruction method and acquisition dose. All observers performed better with the PML images than with the FBP images. With the acquisition dose of 0.7 mGy, the average areas under the LROC curve (AL) for the PML and FBP algorithms were 0.69 and 0.43, respectively. For the 1.0-mGy dose, the values of AL were 0.93 (PML) and 0.7 (FBP), while the 1.5-mGy dose resulted in areas of 1.0 and 0.9 respectively for the PML and FBP algorithms. A 2D analysis of variance applied to the individual observer areas showed statistically significant differences (at a significance level of 0.05) between the reconstruction strategies at all three dose levels. There were no significant differences in observer performance for any of the dose levels.