Distribution of CCR2-64I and SDF1-3′A alleles and HIV status in 7 ethnic populations of Cameroon
Distribution of CCR2-64I and SDF1-3′A alleles and HIV status in 7 ethnic populations of Cameroon
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DOI：
10.1097/01.qai.0000157008.66584.d6
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发表时间：
2005-09-01
影响因子：
3.6
通讯作者：
Nyambi, P
中科院分区：
文献类型：
--
作者：
Ma, LY;Marmor, M;Nyambi, P
关于能够抵抗艾滋病毒-1感染或减缓艾滋病毒疾病进展的宿主遗传多态在非洲农村人中的流行情况，现有的信息有限。我们报告了来自喀麦隆7个民族的321名志愿者的艾滋病相关基因CCR2-64I、SDF1-3‘A和CCR5-Delta 32的等位基因频率。等位基因频率CCR2-641为10.8%~31.3%，SDF1-3‘A为0.0%~7.1%，未发现CCR5-Delta 32等位基因。艾滋病毒血清阳性率在总人口中为6.9%，女孩和妇女的血清阳性率在比男孩和男子更年轻的时候达到峰值。在15~54岁人群中，农村人群中HIV血清阳性率为2.0%~11.1%。条件Logistic回归分析显示，CCR2-641等位基因的数量是HIV血清阳性的显著危险因素(根据年龄调整并按种族匹配的每个等位基因的优势比=6.3，95%可信区间：1.3-30.3)；这种关联在女性中未发现。这一发现与CCR2-641等位基因可能延缓HIV疾病进展而不影响男性感染易感性的假设一致。我们没有在女性中观察到这种关系，其他因素，如多胎妊娠或母亲的压力(如母乳喂养)，可能掩盖了CCR2-641等位基因的任何保护作用。有必要在妇女中进一步研究这一问题。在HIV血清阴性的妇女中，随着年龄的增长，SDF1-3‘A在HIV血清阳性和HIV血清阴性的个体中没有差异，这表明对HIV-1感染有保护作用。
Limited information is available on the prevalence among rural Africans of host genetic polymorphisms conferring resistance to HIV-1 infection or slowing HIV disease progression. We report the allelic frequencies of the AIDS-related polymorphisms CCR2-64I, SDF1-3'A, and CCR5-Delta 32 in 321 volunteers from 7 ethnic groups in Cameroon. Allelic frequencies differed among the 7 ethnic groups, ranging from 10.8% to 31.3% for CCR2-641 and 0.0% to 7.1% for SDF1-3'A. No CCR5-Delta 32 alleles were found. HIV seroprevalence was 6.9% in the total population and peaked at younger ages in girls and women than in boys and men. Among 15- to 54-year-olds, HIV seroprevalence varied from 2.0% to 11.1% among the village populations. Conditional logistic regression analysis using data from boys and men aged 15 to 54 years showed the number of CCR2-641 alleles to be a significant risk factor for HIV seropositivity (odds ratio per allele adjusted for age and matched on ethnic group = 6.3, 95% confidence interval: 1.3-30.3);, this association was not found in women. The findings are consistent with the hypothesis that CCR2-641 alleles may delay HIV disease progression without affecting susceptibility to infection among men. We did not observe this relation among women, and other factors, such as multiple pregnancies or maternal stressors (eg, breastfeeding), may have masked any protective effect of CCR2-641 alleles. Further study of this issue among women is warranted. SDF1-3'A did not differ between HIV seropositive and HIV seronegative individuals associated with increasing age among HIV-seronegative women, suggesting a protective effect against HIV-1 infection.