A Physiologically Based Pharmacokinetic Model for Capreomycin
A Physiologically Based Pharmacokinetic Model for Capreomycin
复制标题
基于生理学的卷曲霉素药代动力学模型
DOI：
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发表时间：
2011
影响因子：
4.9
通讯作者：
M. A. Degroote
中科院分区：
文献类型：
--
作者：
B. Reisfeld;C. Metzler;M. A. Lyons;A. N. Mayeno;Elizabeth J. Brooks;M. A. Degroote
ABSTRACT The emergence of multidrug-resistant tuberculosis (MDR-TB) has led to a renewed interest in the use of second-line antibiotic agents. Unfortunately, there are currently dearths of information, data, and computational models that can be used to help design rational regimens for administration of these drugs. To help fill this knowledge gap, an exploratory physiologically based pharmacokinetic (PBPK) model, supported by targeted experimental data, was developed to predict the absorption, distribution, metabolism, and excretion (ADME) of the second-line agent capreomycin, a cyclic peptide antibiotic often grouped with the aminoglycoside antibiotics. To account for interindividual variability, Bayesian inference and Monte Carlo methods were used for model calibration, validation, and testing. Along with the predictive PBPK model, the first for an antituberculosis agent, this study provides estimates of various key pharmacokinetic parameter distributions and supports a hypothesized mechanism for capreomycin transport into the kidney.
影响因子：
28.2
作者：
Fu, Li M.;Shinnick, Thomas M.
通讯作者：
Shinnick, Thomas M.