Effects of gonadal hormone replacement on measures of basal forebrain cholinergic function
Effects of gonadal hormone replacement on measures of basal forebrain cholinergic function
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DOI：
10.1016/s0306-4522(00)00433-4
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发表时间：
2000-01-01
期刊：
影响因子：
3.3
通讯作者：
Gibbs, RB
中科院分区：
文献类型：
--
作者：
Gibbs, RB
通过测定去卵巢成年大鼠脑内胆碱乙酰转移酶活性和高亲和力胆碱摄取的变化，观察不同激素替代方案对大鼠基底前脑胆碱能功能的影响。重复使用雌激素和黄体酮治疗2周后，在额叶皮质(20.1%)和嗅球(30.4%)中检测到胆碱乙酰转移酶活性增加，而不是4周。连续服用雌激素、重复服用黄体酮或重复服用雌激素+黄体酮两周后，高亲和力胆碱摄取率在额叶皮质(39.5-55.1%)、海马体(34.9-48.9%)和嗅球(29.9%)中增加，而不是四周。重复服用雌二醇(2-25杯/250克体重)2周或4周，连续服用雌激素4周和6个月，对海马区、额叶皮质或嗅球的胆碱乙酰转移酶活性或高亲和力胆碱摄取无明显影响。连续服用雌激素13个月，所有区域的高亲和力胆碱摄取均显著降低，其中以海马区的效果最大(-28.1%)。结果表明，短期服用雌激素和/或孕酮可以显著增强基底前脑胆碱能投射特定靶点的胆碱能功能。最重要的是，根据激素替代的方式和方案的不同，效果有很大的不同，并没有在长期治疗中持续下去。这些发现可能对有效使用激素替代策略预防和治疗阿尔茨海默病和女性年龄相关性认知下降具有重要意义。(C)2000年IBRO。爱思唯尔科学有限公司出版。版权所有。
The effects of different hormone replacement regimens on basal forebrain cholinergic function were examined by measuring changes in choline acetyltransferase activity and high affinity choline uptake in adult, ovariectomized, rats. Increases in choline acetyltransferase activity were detected in the frontal cortex (20.1%) and olfactory bulbs (30.4%) following two weeks, but not four weeks, of repeated treatment with estrogen plus progesterone. Increases in high affinity choline uptake were detected in the frontal cortex (39.5-55.1%), hippocampus (34.9-48.9%), and olfactory bulbs (29.9%) after two weeks, but not four weeks, of either continuous estrogen administration, repeated progesterone administration, or repeated treatment with estrogen plus progesterone. Repeated administration of estradiol (2-25 mug/250 g body weight) for two or four weeks, and continuous estrogen administration for four weeks and six months, produced no significant changes in choline acetyltransferase activity or high affinity choline uptake in the hippocampus, frontal cortex or olfactory bulbs. Continuous estrogen administration for 13 months produced a significant decrease in high affinity choline uptake across all regions with the largest effect (-28.1%) detected in the hippocampus.The findings demonstrate that short-term treatment with estrogen and/or progesterone can significantly enhance cholinergic function within specific targets of the basal forebrain cholinergic projections. Most important is the fact that the effects varied considerably according to the manner and regimen of hormone replacement and did not persist with prolonged treatment. These findings could have important implications for the effective use of hormone replacement strategies in the prevention and treatment of Alzheimer's disease and age-related cognitive decline in women. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.