The evolving role of immune cells in prostate cancer
The evolving role of immune cells in prostate cancer
复制标题
免疫细胞在前列腺癌中不断演变的作用。
DOI：
10.1016/j.canlet.2021.10.027
复制
发表时间：
2021-10-30
期刊：
影响因子：
9.7
通讯作者：
Gao, Wei-Qiang
中科院分区：
文献类型：
--
作者：
Wang, Chao;Zhang, Yan;Gao, Wei-Qiang
前列腺癌是最常见的癌症，也是西方国家男性癌症相关死亡的第二大原因。雄激素剥夺疗法（ADT）被认为是复发性前列腺癌的标准治疗方法；然而，这种治疗可能导致ADT抵抗和肿瘤进展，这似乎是由上皮-间质转化（EMT）和/或神经内分泌分化（NED）调节的。此外，最近的数据表明，适应性或先天浸润性免疫细胞参与前列腺癌的发生、进展、转移和治疗。在这篇综述中，我们概述了这些免疫细胞在前列腺癌的发生、发展、转移和治疗中的特点和作用。我们还总结了目前针对前列腺肿瘤微环境免疫细胞的治疗策略。
Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer-related death among men in western countries. Androgen deprivation therapy (ADT) is considered the standard therapy for recurrent prostate cancer; however, this therapy may lead to ADT resistance and tumor progression, which seems to be regulated by epithelial-mesenchymal transition (EMT) and/or neuroendocrine differentiation (NED). In addition, recent data suggested the involvement of either adaptive or innate infiltrated immune cells in the initiation, progression, metastasis, and treatment of prostate cancer. In this review, we outlined the characteristics and roles of these immune cells in the initiation, progression, metastasis, and treatments of prostate cancer. We also summarized the current therapeutic strategies in targeting immune cells of the prostate tumor microenvironment.