Short-term depression of synaptic transmission from rat lateral geniculate nucleus to primary visual cortex in vivo
Short-term depression of synaptic transmission from rat lateral geniculate nucleus to primary visual cortex in vivo
复制标题
DOI：
10.1016/j.brainres.2004.01.001
复制
发表时间：
2004-03-26
期刊：
影响因子：
2.9
通讯作者：
Zhou, YF
中科院分区：
文献类型：
--
作者：
Jia, F;Xie, XQ;Zhou, YF
成年大鼠膝皮层视觉通路存在两种短期突触可塑性，即配对脉冲抑制（PPD）和频率抑制。GABAa受体拮抗剂（双库兰甲碘胺）或GABAb受体拮抗剂（2-羟基-沙氯芬）在初级视觉皮层的离子透入可显著减轻短期突触抑制。阻断NMDA或AMPA/kainate受体后，突触抑制未见明显变化。高[Ca2+]的应用增强了短期突触抑制。我们的研究结果表明，突触前Ca2+依赖的神经递质耗竭和突触后gaba能抑制可能是短期突触抑制的关键。(C) 2004 Elsevier B.V.版权所有
Two forms of short-term synaptic plasticity, paired-pulse depression (PPD) and frequency depression, were prominent in the adult rat geniculo-cortical visual pathway in vivo. Iontophoresis of GABAa receptor antagonist (bicuculline methiodide) or GABAb receptor antagonist (2-hydroxy-saclofen) in the primary visual cortex significantly reduced the short-term synaptic depression. When NMDA or AMPA/kainate receptors were blocked, no obvious change of synaptic depression was observed. Application of high [Ca2+] enhanced the short-term synaptic depression. Our results suggest that the presynaptic Ca2+-dependent neurotransmitter depletion and postsynaptic GABAergic inhibition may be crucial for short-term synaptic depression in the geniculo-cortical pathway. (C) 2004 Elsevier B.V. All rights reserved.