Multi-physics Analysis of Electromagnetic Wave Propagation and Photothermal Heating in Human Tissues at Terahertz and Optical Frequencies
Multi-physics Analysis of Electromagnetic Wave Propagation and Photothermal Heating in Human Tissues at Terahertz and Optical Frequencies
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DOI：
10.1109/dcoss54816.2022.00064
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发表时间：
2022-05
期刊：
影响因子：
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通讯作者：
I. Reddy;J. Jornet
中科院分区：
文献类型：
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作者：
I. Reddy;J. Jornet
我们提出了一个定制的，多物理模型来研究电磁波在极端随机介质中的传播，如人体组织，并研究其随后的光热效应。所提出的有限元模型由两个部分组成-第一部分估计沿着光束路径的强度分布，而第二部分计算由于组织内的波分布引起的温度升高。我们确定的强度变化的组织中使用的辐射传输方程，并与蒙特卡罗分析和现有的分析模型的结果进行比较。然后利用强度信息来预测由Pennes的生物热方程驱动的生物热传递模块的温度上升。该模型是参数化的，我们进行了系统的光热分析，以识别组织内温度增长的关键变量，特别是太赫兹和近红外光学频率。我们的数值模型可以作为一个基准，涉及复杂的异质介质的体内通信研究。
We present a custom-built, multi-physics model to investigate electromagnetic wave propagation in extreme random media such as human tissue and study its subsequent photothermal effects. The proposed finite-element model consists of two segments – the first one estimates the intensity distribution along the beam path, while the second calculates the increase in temperature due to the wave distribution inside the tissue. We determine the intensity variation in the tissue using the radiative transfer equation and compare the results with Monte Carlo analysis and existing analytical models. The intensity information is then utilized to predict the rise in temperature with a bio-heat transfer module, powered by Pennes’ bioheat equation. The model is parametric, and we perform a systematic photothermal analysis to recognize the crucial variables responsible for the temperature growth inside the tissue, particularly for terahertz and near infrared optical frequencies. Our numerical model can serve as a benchmark for intrabody communication studies involving complex heterogeneous media.