Mitochondrial Respiratory Efficiency is Positively Correlated With Human Sperm Motility
Mitochondrial Respiratory Efficiency is Positively Correlated With Human Sperm Motility
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DOI：
10.1016/j.urology.2011.12.042
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发表时间：
2012-04-01
期刊：
影响因子：
2.1
通讯作者：
Zara, Vincenzo
中科院分区：
文献类型：
--
作者：
Ferramosca, Alessandra;Provenzano, Sara Pinto;Zara, Vincenzo
目的将精子线粒体呼吸效率与精子活力变化和精子形态异常联系起来。方法通过在低渗处理的精子细胞中进行的耗氧量极谱分析来评估精子线粒体呼吸活性。研究了精子线粒体呼吸效率、精子活力和形态异常之间可能的关系。结果线粒体呼吸效率与精子活力呈正相关，与不动精子的百分比呈负相关。此外，中段缺陷会损害线粒体功能。结论我们的数据表明，精子活力的增加需要线粒体呼吸能力的平行增加，从而支持线粒体氧化磷酸化在正常精子受试者精子活力中发挥的基本作用。这些结果具有病理生理学相关性，因为它们表明精子线粒体功能和能量产生的紊乱可能是弱精子症的原因。泌尿学 79: 809-814, 2012。(C) 2012 Elsevier Inc.
OBJECTIVE To correlate sperm mitochondrial respiratory efficiency with variations in sperm motility and with sperm morphologic anomalies.METHODS Sperm mitochondrial respiratory activity was evaluated with a polarographic assay of oxygen consumption carried out in hypotonically-treated sperm cells. A possible relationship among sperm mitochondrial respiratory efficiency, sperm motility, and morphologic anomalies was investigated.RESULTS Mitochondrial respiratory efficiency was positively correlated with sperm motility and negatively correlated with the percentage of immotile spermatozoa. Moreover, midpiece defects impaired mitochondrial functionality.CONCLUSION Our data indicate that an increase in sperm motility requires a parallel increase in mitochondrial respiratory capacity, thereby supporting the fundamental role played by mitochondrial oxidative phosphorylation in sperm motility of normozoospermic subjects. These results are of physiopathological relevance because they suggest that disturbances of sperm mitochondrial function and of energy production could be responsible for asthenozoospermia. UROLOGY 79: 809-814, 2012. (C) 2012 Elsevier Inc.