Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules.
Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules.
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DOI：
10.1084/jem.144.3.828
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发表时间：
1976-09-01
期刊：
影响因子：
--
通讯作者：
Woodruff JJ
中科院分区：
文献类型：
--
作者：
Stamper HB Jr;Woodruff JJ
描述了用于研究淋巴细胞和淋巴结高内皮小静脉 (HEV) 之间相互作用的体外模型。大鼠或小鼠淋巴细胞在同源淋巴结固定切片上分层，选择性地粘附到 HEV 的内皮细胞上，但不与其他血管内皮细胞结合。有证据表明，体外对 HEV 的粘附是再循环淋巴细胞的特性，而不是体内无法归巢到淋巴结的细胞的特征。
An in vitro model is described for studying the interaction between lymphocytes and high-endothelial venules (HEV) of lymph nodes. Rat or mouse lymphocytes which were layered over fixed sections of syngeneic lymph nodes adhered selectively to the endothelium of HEV but did not bind to other vascular endothelia. Evidence is presented that adherence to HEV in vitro is a property of recirculating lymphocytes and not a characteristic of cells which are unable to home into lymph nodes in vivo.