Modulation of feeding-induced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state
Modulation of feeding-induced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state
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DOI：
10.1046/j.1460-9568.1999.00843.x
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发表时间：
1999-12-01
影响因子：
3.4
通讯作者：
Di Chiara, G
中科院分区：
文献类型：
--
作者：
Bassareo, V;Di Chiara, G
我们先前已经在非剥夺大鼠中表明，喂食不熟悉的可口食物（Fonzies（））阶段性地刺激内侧核（NAc）中的体内多巴胺（DA）传递，并且这种效应在先前（24小时）Fonzies餐后经历习惯化（Bassareo & Di Chiara 1997，J. Neurosci.，17，851-861）。目前的研究表明，一种味道和成分（牛奶巧克力）与Fonzies不同的陌生食物（金德（（R）也诱导了NAc中DA的释放。习惯化是味觉特异性的，因为在Fonzies和金德之间没有观察到交叉习惯化。在未被剥夺自由的大鼠中，40分钟暴露于内在的食欲刺激（来自Fonzies填充塑料盒的食物气味）也阻止了与Fonzies喂养相关的透析液DA的增加，并且这种影响部分被食物剥夺逆转。食物剥夺也阻止了Fonzies诱导的NAc中透析液DA增加的习惯化。预测协会的一个空的塑料盒Fonzies喂养导致收购的食欲属性的框和促进（而不是抑制）的阶段性反应DA传输Fonzies喂养。一个10分钟的预暴露于Fonzies固有的食欲嗅觉刺激仍然防止，如40分钟的预暴露，NAC DA反应Fonzies喂养;然而，5分钟的预暴露于这些食欲刺激并没有阻止DA反应的NAC。这些结果表明，NAc DA传输到一个不熟悉的可口的食物的相位响应下的初级（消费）和二级（食欲）刺激的强烈调制控制，这种控制的迹象和程度取决于食欲刺激的性质，延迟奖励和动机状态（剥夺）。
We have previously shown in non-deprived rats that feeding of an unfamiliar palatable food (Fonzies((R))) phasically stimulates in vivo dopamine (DA) transmission in the medial nucleus accumbens (NAc) and this effect undergoes habituation after a previous (24 h) Fonzies meal (Bassareo & Di Chiara 1997, J. Neurosci., 17, 851-861). The present study shows that an unfamiliar food (Kinder((R))) with a taste and composition (milk chocolate) different from that of Fonzies, also induces a release of DA in the NAc subjected to one-trial habituation. Habituation was taste specific as no cross-habituation was observed between Fonzies and Kinder. In undeprived rats, a 40-min exposure to an intrinsic appetitive stimulus (food smell arising from a Fonzies-filled plastic box) also prevented the increase in dialysate DA associated with Fonzies feeding, and this effect was partially reversed by food deprivation. Food deprivation also prevented habituation of Fonzies-induced increase of dialysate DA in the NAc. Predictive association of an empty plastic box to Fonzies feeding resulted in the acquisition of appetitive properties by the box and in facilitation (rather than inhibition) of the phasic responsiveness of DA transmission to Fonzies feeding. A 10-min pre-exposure to appetitive olfactory stimuli intrinsic to Fonzies still prevented, like a 40-min pre-exposure, the NAc DA response to Fonzies feeding; however, a 5-min pre-exposure to these appetitive stimuli did not prevent the DA response in the NAc. These results show that the phasic responsiveness of NAc DA transmission to an unfamiliar palatable food is under strong modulatory control by primary (consummatory) and secondary (appetitive) stimuli, and that the sign and extent of this control depends on the nature of the appetitive stimulus, delay of reward and motivational state (deprivation).