Reduction of the sevoflurane minimum alveolar concentration induced by methadone, tramadol, butorphanol and morphine in rats
Reduction of the sevoflurane minimum alveolar concentration induced by methadone, tramadol, butorphanol and morphine in rats
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DOI：
10.1258/la.2012.010066
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发表时间：
2012-07-01
影响因子：
2.4
通讯作者：
Gomez de Segura, Ignacio A.
中科院分区：
文献类型：
--
作者：
Abreu, Mariana;Aguado, Delia;Gomez de Segura, Ignacio A.
本研究旨在估计大鼠中低和高剂量美沙酮（5和10 mg/kg）、曲马多（25和50 mg/kg）、布托啡诺（5和10 mg/kg）或吗啡（5和10 mg/kg）诱导的七氟烷最低肺泡浓度（MAC）降低。对照组给予生理盐水。用七氟烷麻醉63只成年雄性Sprague-Dawley大鼠（每组n = 7）。然后在腹腔内给予阿片类药物或生理盐水之前和之后测定七氟烷MAC。还记录了七氟烷MAC降低的持续时间以及基本的心血管和呼吸测量值。基线MAC为2.5（0.3）vol%。美沙酮、曲马多和吗啡以剂量依赖性方式降低七氟烷MAC（低剂量：分别为31 +/- 10、38 +/- 15和30 +/- 13%;高剂量：分别为100 +/- 0、83 +/- 17和77 +/-25%）。低剂量和高剂量布托啡诺降低七氟烷MAC的程度相似（低剂量和高剂量分别为33 +/- 7和31 +/-4%）。2只大鼠在给予高剂量布托啡诺和美沙酮后发生呼吸暂停。这些麻醉保护作用具有临床相关性，可减少与高剂量吸入麻醉剂相关的不良反应。
This study aimed to estimate the reduction in the minimum alveolar concentration (MAC) of sevoflurane induced by low and high doses of methadone (5 and 10 mg/kg), tramadol (25 and 50 mg/kg), butorphanol (5 and 10 mg/kg) or morphine (5 and 10 mg/kg) in the rat. A control group received normal saline. Sixty-three adult male Sprague-Dawley rats were anaesthetized with sevoflurane (n = 7 per group). Sevoflurane MAC was then determined before and after intraperitoneal administration of the opioids or saline. The duration of the sevoflurane MAC reduction and basic cardiovascular and respiratory measurements were also recorded. The baseline MAC was 2.5 (0.3) vol%. Methadone, tramadol and morphine reduced the sevoflurane MAC (low dose: 31 +/- 10, 38 +/- 15 and 30 +/- 13% respectively; high dose: 100 +/- 0, 83 +/- 17 and 77 +/- 25%, respectively) in a dose-dependent manner. The low and high doses of butorphanol reduced the sevoflurane MAC to a similar extent (33 +/- 7 and 31 +/- 4%, low and high doses, respectively). Two rats developed apnoea following administration of high-dose butorphanol and methadone. These anaesthetic-sparing effects are clinically relevant and may reduce the adverse effects associated with higher doses of inhalational anaesthetics.