A method for assessing metabolic information on liver and bone marrow by use of double gradient-echo with spectral fat suppression.
A method for assessing metabolic information on liver and bone marrow by use of double gradient-echo with spectral fat suppression.
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一种利用双梯度回波和光谱脂肪抑制来评估肝脏和骨髓代谢信息的方法。
DOI：
10.1007/s12194-013-0254-x
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Shibamoto Y.
中科院分区：
文献类型：
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作者：
Kasai H;Miyati T;Kawai T;Kan H;Kawano M;Shibamoto Y.
在这项研究中，我们的目的是创建一种无创和实用的方法来评估肝脏（铁含量和脂质浸润）和脊柱（骨密度和骨髓脂肪变性）的代谢信息，使用双梯度回波，有和没有光谱脂肪抑制技术（双gres - fs）。我们将不同浓度的超顺磁性氧化铁溶液与中性脂肪相邻排列，利用部分体积效应获得不同脂肪分数的薄片。我们获得双greg - fs图像并计算T2*值。通过T2*衰减、基线和斜率校正后的双gre - fs图像的信号强度计算脂肪分数。我们评估了脂肪含量以及水组分R2*与铁浓度的关系。此外，我们在人类骨髓和肝脏中评估了这些值，包括肝脂肪变性患者。实际脂肪分数值与双gre - fs法所得脂肪分数值一致，计算脂肪分数不受铁浓度的影响。水组分R2*与铁浓度呈较强的正相关。脂肪含量与骨密度呈负相关，R2*与骨密度呈相关。肝脂肪变性患者的计算脂肪分数明显高于健康志愿者。双gre - fs可以同时评估脂肪分数和R2*，并获得肝脏和骨髓的代谢信息。
Our aim in this study was to create a noninvasive and practical method for evaluating metabolic information on the liver (iron content and lipid infiltration) and spine (bone mineral density and marrow fat degeneration) using double gradient-echo with and without the spectral fat suppression technique (double-GRE–FS). We arranged phantoms made of various concentrations of superparamagnetic iron oxide solution adjacent to neutral fat to obtain slice planes with various fat fractions using the partial volume effect. We obtained double-GRE–FS images and calculated the T2* values. The fat fraction was calculated from signal intensities of double-GRE–FS images after T2* decay, baseline, and slope corrections. We assessed the fat fraction and the relationship between R2* of the water component and the iron concentration. In addition, we evaluated those values in human bone marrow and liver, including a patient with liver steatosis. The actual fat fraction value was consistent with the fat fraction obtained with the double-GRE–FS method, and the calculated fat fraction was unaffected by the iron concentration. There was a strong positive correlation between R2* of the water component and the iron concentration. There was a negative correlation between the fat fraction and the bone mineral density, and the R2* was correlated with the bone mineral density. The calculated fat fraction in the liver steatosis patient was significantly higher than that in healthy volunteers. The double-GRE–FS makes it possible to assess the fat fraction and R2* simultaneously, and to obtain metabolic information on the liver and bone marrow.