Growth Factors and Cytokines in Acute Lung Injury
Growth Factors and Cytokines in Acute Lung Injury
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DOI：
10.1002/cphy.c090011
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发表时间：
2011-01-01
影响因子：
5.8
通讯作者：
Standiford, Theodore J.
中科院分区：
文献类型：
--
作者：
Deng, Jane C.;Standiford, Theodore J.
细胞因子和生长因子在维持免疫稳态、产生保护性免疫和肺修复过程中起着不可或缺的作用。然而，响应于感染性或有害性损伤的细胞因子和生长因子的失调表达可以引发并延续有害的肺部炎症和纤维增生。在这篇文章中，我们将全面审查的贡献，个别细胞因子和生长因子和细胞因子网络的关键病理生理事件在人类和实验性急性肺损伤（ALI），包括炎症细胞募集和激活，肺泡上皮损伤和修复，血管生成，基质沉积和重塑。探讨细胞因子/生长因子作为人类ALI预后指标和治疗靶点的应用。(C)2011年美国生理学会。Compr Physiol 1：81-104，2011.
Cytokines and growth factors play an integral role in the maintenance of immune homeostasis, the generation of protective immunity, and lung reparative processes. However, the dysregulated expression of cytokines and growth factors in response to infectious or noxious insults can initiate and perpetuate deleterious lung inflammation and fibroproliferation. In this article, we will comprehensively review the contribution of individual cytokines and growth factors and cytokine networks to key pathophysiological events in human and experimental acute lung injury (ALI), including inflammatory cell recruitment and activation, alveolar epithelial injury and repair, angiogenesis, and matrix deposition and remodeling. The application of cytokines/growth factors as prognostic indicators and therapeutic targets in human ALI is explored. (C) 2011 American Physiological Society. Compr Physiol 1:81-104, 2011.