Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36
Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36
复制标题
DOI：
10.1086/302287
复制
发表时间：
1999-03-01
影响因子：
9.8
通讯作者：
Ostrander, EA
中科院分区：
文献类型：
--
作者：
Gibbs, M;Stanford, JL;Ostrander, EA
结合70个具有前列腺癌（PC）高风险的家庭的基因组筛选数据，以及这些家庭和另外71个家庭的候选区域映射数据，我们将潜在的遗传性PC易感基因定位于染色体1p36。由于在一些PC高危家族的研究中观察到了过多的原发性脑癌（BC）病例，并且由于在BC中经常观察到1p36杂合性缺失，我们进一步评估了12个既有PC病史又有原发性BC血亲的家族。这12个家族的总体LOD评分为3.22，重组分数（θ）为0.06，标记为D1S507。根据先验假设，按诊断PC时的年龄对该组进行分层。在较年轻的年龄组（诊断时的平均年龄
Combining data from a genomic screen in 70 families with a high risk for prostate cancer (PC) with data from candidate-region mapping in these families and an additional 71 families, we have localized a potential hereditary PC-susceptibility locus to chromosome 1p36. Because an excess of cases of primary brain cancer (BC) have been observed in some studies of families with a high risk for PC, and because loss of heterozygosity at 1p36 is frequently observed in BC, we further evaluated 12 families with both a history of PC and a blood relative with primary BC. The overall LOD score in these 12 families was 3.22 at a recombination fraction (theta) of .06, with marker D1S507. On the basis of an a priori hypothesis, this group was stratified by age at diagnosis of PC. In the younger age group (mean age at diagnosis