Transcription Factors in Eosinophil Development and As Therapeutic Targets.
Transcription Factors in Eosinophil Development and As Therapeutic Targets.
复制标题
DOI：
10.3389/fmed.2017.00115
复制
发表时间：
2017
影响因子：
3.9
通讯作者：
Fulkerson PC
中科院分区：
文献类型：
--
作者：
Fulkerson PC
动态基因表达是指导造血细胞命运和分化的主要调控机制，包括嗜酸性粒细胞谱系定型和嗜酸性粒细胞分化。虽然加塔-1已被公认为嗜酸性粒细胞发育的关键转录因子（TF），但描述在稳态和炎症状态下调节嗜酸性粒细胞发育的转录网络并不完整。然而，最近的进展，在分子实验工具，使用纯化的嗜酸性粒细胞发育阶段，导致识别新的调节基因表达嗜酸性粒细胞的发展。在此，最近的研究提供了新的见解嗜酸性粒细胞谱系承诺和嗜酸性粒细胞分化过程中的基因调控机制。描述了一种模型，其中不同类别的TF通过协作和分级相互作用一起工作以指导嗜酸性粒细胞的发育。此外，靶向TF调节嗜酸性粒细胞产生的治疗潜力进行了讨论。了解特定信号如何指导嗜酸性粒细胞特殊功能所需的不同基因表达模式，可能会导致治疗干预的新靶点。
Dynamic gene expression is a major regulatory mechanism that directs hematopoietic cell fate and differentiation, including eosinophil lineage commitment and eosinophil differentiation. Though GATA-1 is well established as a critical transcription factor (TF) for eosinophil development, delineating the transcriptional networks that regulate eosinophil development at homeostasis and in inflammatory states is not complete. Yet, recent advances in molecular experimental tools using purified eosinophil developmental stages have led to identifying new regulators of gene expression during eosinophil development. Herein, recent studies that have provided new insight into the mechanisms of gene regulation during eosinophil lineage commitment and eosinophil differentiation are reviewed. A model is described wherein distinct classes of TFs work together via collaborative and hierarchical interactions to direct eosinophil development. In addition, the therapeutic potential for targeting TFs to regulate eosinophil production is discussed. Understanding how specific signals direct distinct patterns of gene expression required for the specialized functions of eosinophils will likely lead to new targets for therapeutic intervention.