Aqueous Plasma Pharmacy: Preparation Methods, Chemistry, and Therapeutic Applications.
Aqueous Plasma Pharmacy: Preparation Methods, Chemistry, and Therapeutic Applications.
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DOI：
10.1615/plasmamed.2016018618
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Hybertson, Brooks M
中科院分区：
文献类型：
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作者：
Joslin, Jessica M;McCall, James R;Hybertson, Brooks M
血浆药房是血浆医学更广泛领域的一个子集。虽然没有严格定义，但术语水性血浆药物（APP）用于指在水溶液中产生和分布反应性血浆产生的物质，随后施用以获得治疗益处。APP试图在各种应用中利用水溶液中等离子体产生的氧化剂物质的治疗效果，例如消毒剂溶液、与伤口愈合相关的细胞增殖和癌症治疗。随后在APP方法中使用等离子体生成的溶液有助于将反应性等离子体物质递送到体内的内部位置。虽然在等离子体医学领域的重大努力集中在采用直接等离子体羽流暴露于细胞或组织，在这里，我们特别关注在水溶液中的等离子体放电，以使该溶液具有生物活性，用于后续应用。等离子体放电在溶液中的方法进行了审查，沿着与水等离子体化学和APP的应用。该领域的未来还讨论了必要的研究工作，将使商业化的临床部署。
Plasma pharmacy is a subset of the broader field of plasma medicine. Although not strictly defined, the term aqueous plasma pharmacy (APP) is used to refer to the generation and distribution of reactive plasma-generated species in an aqueous solution followed by subsequent administration for therapeutic benefits. APP attempts to harness the therapeutic effects of plasma-generated oxidant species within aqueous solution in various applications, such as disinfectant solutions, cell proliferation related to wound healing, and cancer treatment. The subsequent use of plasma-generated solutions in the APP approach facilitates the delivery of reactive plasma species to internal locations within the body. Although significant efforts in the field of plasma medicine have concentrated on employing direct plasma plume exposure to cells or tissues, here we focus specifically on plasma discharge in aqueous solution to render the solution biologically active for subsequent application. Methods of plasma discharge in solution are reviewed, along with aqueous plasma chemistry and the applications for APP. The future of the field also is discussed regarding necessary research efforts that will enable commercialization for clinical deployment.