An alternative, nonapoptotic form of programmed cell death
An alternative, nonapoptotic form of programmed cell death
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DOI：
10.1073/pnas.97.26.14376
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发表时间：
2000-12-19
影响因子：
11.1
通讯作者：
Bredesen, DE
中科院分区：
文献类型：
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作者：
Sperandio, S;de Belle, I;Bredesen, DE
术语“细胞凋亡”经常与术语“程序性细胞死亡”交替使用。在这里，我们描述了一种细胞程序性死亡的形式，它在形态、生化和对凋亡抑制剂的反应标准上不同于凋亡。在形态上，这种程序性细胞死亡的另一种形式出现在发育过程中，也出现在神经退化的情况下。尽管它对caspase抑制剂和Bclx(L)缺乏反应，但我们发现这种形式的细胞死亡是由另一种caspase-9活性驱动的，该活性不依赖于APAF-1。对这种程序性细胞死亡的替代农场的描述应该会导致对细胞死亡程序及其在发育和退化中的作用的新的洞察。
The term apoptosis often has been used interchangeably with the term programmed cell death. Here we describe a form of programmed cell death that is distinct from apoptosis by the criteria of morphology, biochemistry, and response to apoptosis inhibitors. Morphologically, this alternative form of programmed cell death appears during development and in same cases of neurodegeneration. Despite its lack of response to caspase inhibitors and Bcl-x(L), we show that this form of cell death is driven by an alternative caspase-9 activity that is Apaf-1-independent. Characterization of this alternative farm of programmed cell death should lead to new insight into cell death programs and their roles in development and degeneration.