Treatment options for HIV-associated tuberculosis
Treatment options for HIV-associated tuberculosis
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DOI：
10.1086/518657
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发表时间：
2007-08-15
影响因子：
6.4
通讯作者：
Whalen, Christopher Curtis
中科院分区：
文献类型：
--
作者：
Onyebujoh, Philip Chukwuka;Ribeiro, Isabela;Whalen, Christopher Curtis
人类免疫缺陷病毒（HIV）感染和结核病（TB）流行之间的恶性互动对国家控制计划和医生个人提出了特殊的挑战。尽管艾滋病毒感染患者的结核病治疗建议与未感染艾滋病毒的患者的结核病治疗建议没有显着差异，但由于卫生系统问题、诊断困难、依从性问题、重叠的不良反应特征和药物相互作用，以及开始有效抗逆转录病毒治疗后出现的矛盾反应，艾滋病毒相关结核病的适当管理变得复杂。在这篇文章中，推荐的治疗策略和新的方法来管理艾滋病毒相关的结核病进行审查，包括辅助治疗和治疗简化的选择。在现有知识框架的局限性的背景下，提出了一个有重点的研究议程。
The vicious interaction between the human immunodeficiency virus (HIV) infection and tuberculosis (TB) pandemics poses special challenges to national control programs and individual physicians. Although recommendations for the treatment of TB in HIV-infected patients do not significantly differ from those for HIV-uninfected patients, the appropriate management of HIV-associated TB is complicated by health system issues, diagnostic difficulties, adherence concerns, overlapping adverse-effect profiles and drug interactions, and the occurrence of paradoxical reactions after the initiation of effective antiretroviral therapy. In this article, recommended treatment strategies and novel approaches to the management of HIV-associated TB are reviewed, including adjuvant treatment and options for treatment simplification. A focused research agenda is proposed in the context of the limitations of the current knowledge framework.