Production of Organic Fine-Crystalline Particles by Using the Liquid-Liquid Interface in an Emulsion
Production of Organic Fine-Crystalline Particles by Using the Liquid-Liquid Interface in an Emulsion
复制标题
利用乳液中的液-液界面生产有机细晶颗粒
DOI：
10.1002/ceat.201200016
复制
发表时间：
2012
影响因子：
2.1
通讯作者：
K. Ito
中科院分区：
文献类型：
--
作者：
Takiyama;H.;K. Ito
反溶剂结晶法由于过饱和度的局部波动会影响生成晶体的质量而带来问题。为了减少过饱和度的局部波动并实现均匀的结晶场，讨论了乳液中液-液界面的利用。本研究的目的是确定结晶的操作条件，以便通过乳液中的反溶剂结晶生产具有所需质量的细晶体。使用牛磺酸/水（原始溶剂）/己烷（反溶剂）/乙醇（偶联溶剂）的四元体系。作为实验结果，获得了微米级的牛磺酸晶体，并且通过利用所提出的四元相图澄清了获得所需晶体形状的操作条件。
The method of anti‐solvent crystallization poses problems due to high local fluctuations in supersaturation affecting the quality of the generated crystals. In order to reduce the local fluctuations in supersaturation and to achieve homogeneous crystallization fields, the utilization of a liquid‐liquid interface in an emulsion is discussed. The purpose of this study was to establish the operating conditions of crystallization in order to produce fine crystals with the desired qualities by anti‐solvent crystallization in an emulsion. A quaternary system of taurine/water (original solvent)/hexane (anti‐solvent)/ethanol (coupled solvent) was used. As the experimental result, micro‐sized taurine crystals were obtained, and the operation conditions to obtain the desired crystal shape were clarified by utilizing the proposed quaternary phase diagram.