Risk Factors and Outcomes Associated With First-Trimester Fetal Growth Restriction
Risk Factors and Outcomes Associated With First-Trimester Fetal Growth Restriction
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DOI：
10.1001/jama.2010.78
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发表时间：
2010-02-10
影响因子：
120.7
通讯作者：
Jaddoe, Vincent W. V.
中科院分区：
文献类型：
--
作者：
Mook-Kanamori, Dennis O.;Steegers, Eric A. P.;Jaddoe, Vincent W. V.
背景不利的环境暴露导致胎儿生活中的发育适应。母亲的身体特征和生活习惯对妊娠早期胎儿适应和出生后后果的影响尚不清楚。目的确定与妊娠早期生长受限相关的危险因素和结局。设计、设置和参与者前瞻性评估1631名母亲的母亲的身体特征和生活习惯与妊娠早期胎儿胎冠和臀长的关系。随后，我们评估了妊娠早期胎儿生长受限与不良出生结局和出生后2岁前生长加速的风险之间的关系。这项研究是在荷兰鹿特丹进行的。主要观察指标为妊娠10周、0天、13周、6天，超声测量胎儿头臀比。主要分娩结局是早产(胎龄
Context Adverse environmental exposures lead to developmental adaptations in fetal life. The influences of maternal physical characteristics and lifestyle habits on first-trimester fetal adaptations and the postnatal consequences are not known.Objective To determine the risk factors and outcomes associated with first-trimester growth restriction.Design, Setting, and Participants Prospective evaluation of the associations of maternal physical characteristics and lifestyle habits with first-trimester fetal crown to rump length in 1631 mothers with a known and reliable first day of their last menstrual period and a regular menstrual cycle. Subsequently, we assessed the associations of first-trimester fetal growth restriction with the risks of adverse birth outcomes and postnatal growth acceleration until the age of 2 years. The study was based in Rotterdam, the Netherlands. Mothers were enrolled between 2001 and 2005.Main Outcome Measures First-trimester fetal growth was measured as fetal crown to rump length by ultrasound between the gestational age of 10 weeks 0 days and 13 weeks 6 days. Main birth outcomes were preterm birth (gestational age