Examining the association between salivary cortisol levels and subclinical measures of atherosclerosis: The Multi-Ethnic Study of Atherosclerosis
Examining the association between salivary cortisol levels and subclinical measures of atherosclerosis: The Multi-Ethnic Study of Atherosclerosis
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DOI：
10.1016/j.psyneuen.2012.10.007
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发表时间：
2013-07-01
影响因子：
3.7
通讯作者：
Wu, Meihua
中科院分区：
文献类型：
--
作者：
Hajat, Anjum;Diez-Roux, Ana V.;Wu, Meihua
目的：研究唾液皮质醇与亚临床心血管疾病（CVD）、冠状动脉钙化（CAC）和踝臂指数（ABI）的相关性。方法：多种族动脉粥样硬化研究（梅萨）的辅助研究数据，梅萨应激研究，用于分析唾液皮质醇数据收集的相关性，每天6次，3天以上，CAC和ABI。作者使用混合模型重复皮质醇措施嵌套在人，以确定是否与CAC和ABI的具体功能的皮质醇配置文件。结果：共464名参与者被列入CAC分析和610在ABI分析。参与者的平均年龄为65.6岁。在男性和女性中，冠状动脉钙对数增加1个单位与皮质醇早期下降1.77%（95%CI：0.23，3.34）相关。在女性中，低ABI与早期下降幅度较大（-13.95%CI：-25.58，-3.39）和晚期下降幅度较小（1.39%CI：-0.009，2.81）相关，具有统计学意义。皮质醇曲线下面积和清醒就寝斜率与亚临床CVD.Conclusions：这项研究提供了弱支持皮质醇和亚临床动脉粥样硬化的措施之间的联系。我们发现昼夜皮质醇曲线的某些特征与冠状动脉钙化和ABI之间存在关联，但在亚临床测量中，这种关联并不一致。在检测皮质醇测量在一个时间点与一生中发展的健康结果的关联方面存在方法上的挑战。短期机制的研究，联系压力的生理过程有关的早期动脉粥样硬化的发展可能是更多的信息。(C)2012爱思唯尔有限公司保留所有权利。
Objective: To investigate the association between salivary cortisol and two markers of subclinical cardiovascular disease (CVD), coronary calcification (CAC), and ankle-brachial index (ABI).Methods: Data from an ancillary study to the Multi-Ethnic Study of Atherosclerosis (MESA), the MESA Stress Study, were used to analyze associations of salivary cortisol data collected six times per day over three days with CAC and ABI. The authors used mixed models with repeat cortisol measures nested within persons to determine if specific features of the cortisol profile were associated with CAC and ABI.Results: A total of 464 participants were included in the CAC analysis and 610 in the ABI analysis. The mean age of participants was 65.6 years. A 1-unit increase in log coronary calcium was associated with a 1.77% flatter early decline in cortisol (95% CI: 0.23, 3.34) among men and women combined. Among women low ABI was associated with a steeper early decline (-13.95% CI: -25.58, -3.39) and a marginally statistically significant flatter late decline (1.39% CI: -0.009, 2.81). The cortisol area under the curve and wake to bedtime slope were not associated with subclinical CVD.Conclusions: This study provides weak support for the link between cortisol and measures of subclinical atherosclerosis. We found an association between some features of the diurnal cortisol profile and coronary calcification and ABI but associations were not consistent across subclinical measures. There are methodological challenges in detecting associations of cortisol measures at a point in time with health outcomes that develop over a lifetime. Studies of short-term mechanisms linking stress to physiological processes related to the development of early atherosclerosis may be more informative. (C) 2012 Elsevier Ltd. All rights reserved.