Covid-19 transmission, outcome and associated risk factors in cancer patients at the first month of the pandemic in a Spanish hospital in Madrid
Covid-19 transmission, outcome and associated risk factors in cancer patients at the first month of the pandemic in a Spanish hospital in Madrid
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DOI：
10.1007/s12094-020-02381-z
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发表时间：
2020-05-25
影响因子：
3.4
通讯作者：
Lara, M. A.
中科院分区：
文献类型：
--
作者：
Rogado, J.;Obispo, B.;Lara, M. A.
目前还没有确定新冠肺炎癌症患者特征的大型系列报道。我们确定马德里癌症患者和普通人群之间Covid-19感染的累积发病率和死亡率是否存在差异。材料和方法我们回顾了2020年2月1日至4月7日在肿瘤科住院的所有癌症患者的1069份病历。我们描述了Covid-19的累积发病率、治疗结果、死亡率和相关危险因素。结果癌症患者的Covid-19检出率为45/1069，而总人口的检出率为42,450/6,662,000 （p < 0.00001）。死亡率：19/45癌症患者vs 5586/42,450 （p = 0.0001）。死亡率与中位年龄较大相关，经分期和组织学调整（74岁vs 63.5岁，OR 1.06, p = 0.03）。与年龄、分期、组织学、癌症治疗和合并症无关，羟氯喹和阿奇霉素联合治疗的患者有3/18死亡（OR 0.02, p = 0.03）。结论肿瘤患者易感染新冠肺炎，并发症发生率较高。羟氯喹联合阿奇霉素是一种较好的治疗方案。
Background There are no large reported series determining the Covid-19 cancer patient's characteristics. We determine whether differences exist in cumulative incidence and mortality of Covid-19 infection between cancer patients and general population in Madrid. Material and methods We reviewed 1069 medical records of all cancer patients admitted at Oncology department between Feb 1 and April 7, 2020. We described Covid-19 cumulative incidence, treatment outcome, mortality, and associated risk factors. Results We detected 45/1069 Covid-19 diagnoses in cancer patients vs 42,450/6,662,000 in total population (p < 0.00001). Mortality rate: 19/45 cancer patients vs 5586/42,450 (p = 0.0001). Mortality was associated with older median age, adjusted by staging and histology (74 vs 63.5 years old, OR 1.06, p = 0.03). Patients who combined hydroxychloroquine and azithromycin presented 3/18 deaths, regardless of age, staging, histology, cancer treatment and comorbidities (OR 0.02, p = 0.03). Conclusion Cancer patients are vulnerable to Covid-19 with an increase in complications. Combined hydroxychloroquine and azithromycin is presented as a good treatment option.