Regulation of Translation by TOR, eIF4E and eIF2α in Plants: Current Knowledge, Challenges and Future Perspectives.
Regulation of Translation by TOR, eIF4E and eIF2α in Plants: Current Knowledge, Challenges and Future Perspectives.
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DOI：
10.3389/fpls.2017.00644
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发表时间：
2017
影响因子：
5.6
通讯作者：
Castellano MM
中科院分区：
文献类型：
--
作者：
Sesma A;Castresana C;Castellano MM
真核基因表达的一个重要步骤是从信使核糖核酸合成蛋白质，这个过程通常分为三个阶段：起始、延伸和终止。翻译在真核生物中是一个精确调控和保守的过程。然而，在这个王国中，植物特有的翻译起始因子的存在和众所周知的翻译调控途径的缺乏表明，一个全球保守的过程可以在生物中多样化。蛋白质翻译的控制是植物发育和适应环境胁迫的核心方面，但其机制仍然知之甚少。在这里，我们讨论了调控植物翻译启动的主要机制的当前知识，特别关注这个真核王国的奇点。此外，我们强调了最近在这一领域取得的重大突破和今后几年需要应对的主要挑战。
An important step in eukaryotic gene expression is the synthesis of proteins from mRNA, a process classically divided into three stages, initiation, elongation, and termination. Translation is a precisely regulated and conserved process in eukaryotes. The presence of plant-specific translation initiation factors and the lack of well-known translational regulatory pathways in this kingdom nonetheless indicate how a globally conserved process can diversify among organisms. The control of protein translation is a central aspect of plant development and adaptation to environmental stress, but the mechanisms are still poorly understood. Here we discuss current knowledge of the principal mechanisms that regulate translation initiation in plants, with special attention to the singularities of this eukaryotic kingdom. In addition, we highlight the major recent breakthroughs in the field and the main challenges to address in the coming years.