Environmental factors in the development of obesity in identical twins
Environmental factors in the development of obesity in identical twins
复制标题
DOI：
10.1038/sj.ijo.0800923
复制
发表时间：
1999-07-01
影响因子：
4.9
通讯作者：
Rönnemaa, T
中科院分区：
文献类型：
--
作者：
Hakala, P;Rissanen, A;Rönnemaa, T
目的：研究环境因素促进肥胖时，遗传因素是identity.DESIGN：单卵（MZ）双胞胎不一致的超重进行了检查，在住院setting.SUBJECTS停留3天：受试者从芬兰双胞胎队列。研究样本包括23对健康成年MZ双生子（14名女性，9名男性）的BMI差异至少为3 kg/m2，超重双胞胎的平均BMI为29.5 kg/m2，而他们的瘦双胞胎的平均BMI为22.9 kg/m2。通过访谈和标准化问卷调查获得有关能量和营养摄入、饮食行为、体育活动史结果：超重双生子在饮食三因素问卷中的去抑制得分（P=0.007）和饥饿恐惧得分（P=0.005）均高于瘦双生子。在女性中，超重双胞胎的平均每日能量摄入量高于瘦双胞胎（8.8比7.4 MJ; P= 0.045）。在吸烟不一致的双胞胎中，非吸烟者的平均BMI高于吸烟者（BMI 29.7 +/- 4.4 kg/m2 vs 23.8 +/- 3.1 kg/m2; P= 0.031）。结论：男女控制饮食困难和女性高能量摄入与超重有关，与遗传背景无关。吸烟解释了吸烟不一致对之间BMI的差异。个别双胞胎对体重增加的差异可能有不同的原因，导致单个肥胖促进因素的对内差异不显着。生活条件的差异（如家庭和工作相关因素）可能促进了不同的生活习惯，特别是饮食行为，并可能导致同卵双胞胎体重增加的差异。
OBJECTIVE: To study environmental factors promoting obesity when genetic factors are identical.DESIGN: Monozygotic (MZ) twins discordant for overweight were examined during a 3-day stay in an inpatient setting.SUBJECTS: The subjects were selected from the Finnish Twin Cohort. The study sample consisted of 23 healthy adult MZ twin pairs (14 female, nine male) with a difference of at least 3 kg/m(2) in BMI, The mean BMI was 29.5 kg/m(2) for the overweight twins and 22.9 kg/m(2) for their lean co-twins.MEASUREMENTS: Interviews and standardized questionnaires were used to obtain information about energy and nutrient intake, eating behaviour, physical activity history, smoking and other background factors.RESULTS: The overweight co-twins had higher disinhibition scores (P=0.007) and hunger scares (P=0.005) in the 3-factor Eating Questionnaire than their lean co-twins. Among women the mean daily energy intake was higher in the overweight twins than in their lean co-twins (8.8 vs 7.4 MJ; P= 0.045). In the twins discordant for smoking the mean BMI was higher in non-smokers than in smokers (BMI 29.7 +/- 4.4 kg/m(2) vs 23.8 +/- 3.1 kg/m(2); P=; 0.031).CONCLUSIONS: Difficulty in controlling eating in both sexes and high energy intake in women were related to overweight, independent of genetic background. Smoking explained the BMI difference among smoking discordant pairs. It is probable that individual twin pairs had different reasons behind the variation in weight gain resulting in non-significant intrapair differences in single obesity-promoting factors. Difference in living conditions (e.g, family-and work-related factors) may have promoted different living habits, especially eating behaviour, and may have led to different weight gain in identical twins.