ALTITUDE, LOW BIRTH-WEIGHT, AND INFANT-MORTALITY IN COLORADO
ALTITUDE, LOW BIRTH-WEIGHT, AND INFANT-MORTALITY IN COLORADO
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DOI：
10.1001/jama.259.23.3427
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发表时间：
1988-06-17
影响因子：
120.7
通讯作者：
MOORE, LG
中科院分区：
文献类型：
--
作者：
UNGER, C;WEISER, JK;MOORE, LG
出生体重在高海拔地区会降低，但其与婴儿死亡率的关系尚不清楚。我们检查了科罗拉多州1979年至1982年的生命统计记录，以确定高海拔是否增加婴儿死亡率，以及出生体重下降是否有助于观察到的死亡率。宫内发育迟缓会降低出生体重，并使低出生体重婴儿的频率从最低（915至1523米[3000至4999英尺]）到最高（≥ 1000米[3000至4999英尺]）增加一倍。2744米[≥9000英尺]）的高度。低出生体重增加了死亡风险，但低出生体重的死亡风险在高海拔地区比低海拔地区降低，导致全州婴儿死亡率相似。这一发现与1969年至1973年的情况不同，当时高海拔地区的婴儿死亡率翻了一番。在过去的十年里，全州的婴儿死亡率下降了46%，这主要是由于早产低出生体重婴儿的死亡风险降低。这一下降，特别是在高海拔地区，可能是由于更好地识别和运输高危妊娠的医院与三级新生儿治疗中心。
A decrease in birth weight occurs at high altitude, but its relationship to infant mortality is unclear. We examined Colorado vital statistics recorded from 1979 through 1982 to determine whether high altitude increased infant mortality and whether decreased birth weight contributed to the mortality observed. Retardation of intrauterine growth reduced birth weight and doubled the frequency of low-birth-weight infants from the lowest (915 to 1523 m [3000 to 4999 ft] to the highest (.gtoreq. 2744 m [.gtoreq. 9000 ft]) altitude in the state. Low birth weight increased mortality risk, but the mortality risk of low birth weight was decreased at high compared with low altitudes, resulting in similar infant mortality rates throughout the state. This finding differed from that of 1969 through 1973 when infant mortality doubled at high altitude. A 46% infant mortality reduction had occurred statewide over the ten years due chiefly to decreased mortality risk for preterm low-birth-weight infants. This reduction, particularly pronounced at high altitude, might have been due to better identification and transport of high-risk pregnancies to hospitals with tertiary neonatal treatment centers.