Localization of genes involved in the metabolic syndrome using multivariate linkage analysis.
Localization of genes involved in the metabolic syndrome using multivariate linkage analysis.
复制标题
DOI：
10.1186/1471-2156-4-s1-s57
复制
发表时间：
2003-12-31
期刊：
影响因子：
2.9
通讯作者：
de Andrade M
中科院分区：
文献类型：
--
作者：
Olswold C;de Andrade M
对于代谢综合征的诊断，目前还没有被广泛接受的标准。然而，代谢综合征在临床上是通过出现以下五个变量中的三个或更多来确定的：较大的腰围、较高的甘油三酯水平、较低的高密度脂蛋白-胆固醇浓度、高血压和空腹血糖受损。我们使用Framingham心脏研究数据集中可用的两个或三个变量的集合，通过多变量定量连锁分析来定位导致这种综合征的基因。这一分析证明了使用多变量连锁分析的适用性，以及当基因涉及相同的疾病机制时，它的使用如何增加了检测连锁的能力。
There are no well accepted criteria for the diagnosis of the metabolic syndrome. However, the metabolic syndrome is identified clinically by the presence of three or more of these five variables: larger waist circumference, higher triglyceride levels, lower HDL-cholesterol concentrations, hypertension, and impaired fasting glucose. We use sets of two or three variables, which are available in the Framingham Heart Study data set, to localize genes responsible for this syndrome using multivariate quantitative linkage analysis. This analysis demonstrates the applicability of using multivariate linkage analysis and how its use increases the power to detect linkage when genes are involved in the same disease mechanism.