Alcohol ingestion does not affect serum levels of peptide YY but decreases both total and octanoylated ghrelin levels in healthy subjects
Alcohol ingestion does not affect serum levels of peptide YY but decreases both total and octanoylated ghrelin levels in healthy subjects
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DOI：
10.1016/j.metabol.2006.08.003
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发表时间：
2006-12-01
影响因子：
9.8
通讯作者：
Rojdmark, Sven
中科院分区：
文献类型：
--
作者：
Calissendorff, Jan;Danielsson, Olle;Rojdmark, Sven
据报道，酒精对人类有刺激食欲的作用。潜在的机制尚不清楚。胃肠激素，如胃饥饿素和肽YY (PYY)，可能作为酒精效应的介质参与其中，因为胃饥饿素刺激食欲，PYY似乎诱导饱腹感。进行这项调查的目的是研究这个问题。12名年轻健康的男女志愿者参加了2个实验（实验A和B），实验顺序随机，间隔1周。实验A饮用酒精（0.55 g乙醇/ kg），实验b饮用水，在饮用前和饮用后反复采集静脉血。在5小时内测定血清总胃饥饿素、辛烷酰胃饥饿素（激素的生物活性形式）、PYY和乙醇的浓度。实验A中，乙醇浓度在1小时内由0升高到12.5 +/- 0.7 mmol/L (P < 0.001)，然后开始下降。在实验B中，乙醇水平在整个实验过程中保持为零。从30分钟开始，酒精导致总饥饿素和辛烷化饥饿素浓度显著下降。总胃饥饿素水平在饮酒后5小时达到最低点（比基础水平低36% +/- 4%；P < .001）。辛烷酰化胃饥饿素（octanoylated ghrelin）水平在2小时内较基础水平下降48%±5% (P < 0.001)，之后趋于稳定。饮用水对总饥饿素和辛烷化饥饿素水平没有影响。摄入酒精和水后，PYY水平保持不变。酒精对人胃饥饿素分泌有很强的抑制作用，但对循环PYY水平没有影响。这使得酒精的增氧作用不太可能是由这两种激素中的任何一种介导的。(c) 2006爱思唯尔公司版权所有。
Alcohol has been reported to have appetite-stimulating properties in humans. The underlying mechanism is unknown. Gastrointestinal hormones, such as ghrelin and peptide YY (PYY), could be involved as mediators of the alcohol effect because ghrelin stimulates the appetite and PYY appears to induce satiety. This investigation was undertaken with the intention to study that issue. Twelve young and healthy volunteers of both sexes participated in 2 experiments (experiments A and B), which were performed in random order I week apart. Alcohol (0.55 g ethanol per kilogram) was ingested in experiment A, drinking water in experiment B. Venous blood samples were collected before and repeatedly after the drinks. Serum concentrations of total ghrelin, octanoylated ghrelin (the bioactive form of the hormone), PYY, and ethanol were determined over a period of 5 hours. In experiment A, the ethanol level increased from 0 to 12.5 +/- 0.7 mmol/L in 1 hour (P < .001), and then began to decrease. In experiment B, the ethanol level remained at zero throughout the entire experiment. Alcohol induced significant declines in total and octanoylated ghrelin concentrations from 30 minutes on. The total ghrelin level reached its lowest point 5 hours after the alcohol intake (36% +/- 4% below the basal level; P < .001). The octanoylated ghrelin level fell 48% +/- 5% below the basal level in 2 hours ( P < .001) and then tended to level out. Drinking water left both total and octanoylated ghrelin levels unaffected. The PYY level remained unchanged after both alcohol and water ingestion. Alcohol has a strong inhibitory influence on human ghrelin secretion, but has no effect on circulating PYY levels. This makes it unlikely that the orexigenic effect of alcohol is mediated by either of these 2 hormones. (c) 2006 Elsevier Inc. All rights reserved.