Trimethylamine N-oxide as a risk marker for ischemic stroke in patients with atrial fibrillation
Trimethylamine N-oxide as a risk marker for ischemic stroke in patients with atrial fibrillation
复制标题
三甲胺 N-氧化物作为心房颤动患者缺血性中风的风险标志物
DOI：
10.1002/jbt.22246
复制
发表时间：
2019-02-01
影响因子：
3.6
通讯作者：
Hai, Xin
中科院分区：
文献类型：
--
作者：
Liang, Zhaoguang;Dong, Zengxiang;Hai, Xin
三甲胺n -氧化物（TMAO）是心血管疾病的独立危险因素。我们的目的是探讨TMAO与房颤（AF）患者缺血性脑卒中（IS）之间的关系。共有68例合并IS的房颤患者和111例未合并IS的房颤患者入组。IS-AF患者血浆TMAO水平（8.25 +/- 1.58 μ M）明显高于AF患者（2.22 +/- 0.09 μ M, P < 0.01）。受试者工作特征分析显示，TMAO预测AF患者IS的最佳临界值为3.53 μ M，敏感性75.0%，特异性92.8%（曲线下面积0.917,95%可信区间0.877 ~ 0.957）。单因素和多因素logistic回归分析显示TMAO是IS的独立预测因子。TMAO水平与CHA2DS2-VASc评分相关。综上所述，TMAO是IS的独立预测因子，有可能改善AF患者的脑卒中分层。
Trimethylamine N-oxide (TMAO) is an independent risk factor of cardiovascular disease. Our objective was to explore the relation between TMAO and ischemic stroke (IS) in patients with atrial fibrillation (AF). A total of 68 patients with AF with IS and 111 ones without IS were enrolled. The plasma levels of TMAO remarkably increased in IS-AF patients (8.25 +/- 1.58 mu M) compared with patients with AF (2.22 +/- 0.09 mu M, P < 0.01). The receiver operating characteristic analysis revealed that the best cutoff value of TMAO to predict IS in patients with AF was 3.53 mu M with 75.0% sensitivity and 92.8% specificity (area under the curve: 0.917, 95% confidence intervals: 0.877-0.957). Univariate and multivariate logistic regression analysis showed that TMAO was an independent predictor in IS. The level of TMAO was correlated with the CHA2DS2-VASc score. In conclusion, TMAO was an independent predictor of IS, which could potentially refine stroke stratification in patients with AF.