Performance evaluation of the microPET® -: FOCUS-F120
Performance evaluation of the microPET® -: FOCUS-F120
复制标题
DOI：
10.1109/tns.2006.889312
复制
发表时间：
2007-02-01
影响因子：
1.8
通讯作者：
Yap, Jeffrey
中科院分区：
文献类型：
--
作者：
Laforest, Richard;Longford, Desmond;Yap, Jeffrey
microPET (c)-Focus-F120是CTI-Concorde Microsystems LLC （Knoxville， TN）最新型号的专用小动物PET扫描仪。这种扫描器，基于微型pet - r4的几何形状，利用了几个探测器的修改，以提高图像分辨率，灵敏度和计数率性能的巧合处理电子器件，与之前的模型相比。这项工作评估了福克斯- f120系统的性能，并展示了它比早期型号的改进。特别是，与microPET-R4相比，在5 mm径向距离下，空间分辨率从2.32 mm提高到1.69 mm，峰值绝对灵敏度从4.1%提高到1.1%。计数率能力，以噪声等效计数率（NEC-1R）表示，在88 MBq的情况下，两种系统都显示出超过800 kcps的峰值。对于这个小的幻影，NECR计数率受到扫描仪和采集控制台之间的数据传输带宽的限制。大鼠样幻像在300 kcps， 140 MBq时出现峰值NEC-1R值。利用专门设计的模型和动物实验对图像质量和定量精度进行了评价。
microPET (c)-Focus-F120 is the latest model of dedicated small animal PET scanners from CTI-Concorde Microsystems LLC, (Knoxville, TN). This scanner, based on the geometry of the microPET-R4, takes advantage of several detector modifications, to the, coincidence processing electronics that improve the image resolution, sensitivity, and counting rate performance as compared to the predecessor models. This work evaluates the performance of the Focus-F120 system and shows its improvement over the earlier models. In particular, the spatial resolution is shown to improve from 2.32 to 1.69 mm at 5 mm radial distance and the peak absolute sensitivity increases from 4.1% to 1.1% compared to the microPET-R4. The counting rate capability, expressed in noise equivalent counting rate (NEC-1R), was shown to peak at over 800 kcps at 88 MBq for both systems using a mouse phantom. For this small phantom, the NECR counting rate is limited by the data transmission bandwidth between the scanner and the acquisition console. The rat-like phantom showed peak NEC-1R value at 300 kcps at 140 MBq. Evaluation of image quality and quantitation accuracy was also performed using specially designed phantoms and animal experiments.