Signaling Recognition Events with Fluorescent Sensors and Switches
Signaling Recognition Events with Fluorescent Sensors and Switches
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DOI：
10.1002/chin.199744337
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发表时间：
1997-10
期刊：
影响因子：
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通讯作者：
A. P. D. Silva;H. Gunaratne;T. Gunnlaugsson;Allen J. M. Huxley;C. McCoy;J. Rademacher;Terence E. Rice
中科院分区：
文献类型：
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作者：
A. P. D. Silva;H. Gunaratne;T. Gunnlaugsson;Allen J. M. Huxley;C. McCoy;J. Rademacher;Terence E. Rice
化学、生物学和材料科学的关键认知事件发生在一个比我们所习惯的小得多的世界里。有关这些事件的信息可以通过特制的分子装置发出的光信号方便地传递给我们。1r8除了这种感觉作用之外，9r30这种分子器件还具有信息处理的潜力，因为它们的发射可以通过环境刺激在两种可区分的状态之间切换。在这篇综述中，我们强调了这种系统的独特性和实用性。值得注意的是，这些手段为不同类别的受益人提供服务，他们的需要和方法各不相同。分析化学家和环境科学家通常需要传感器分子的群体，这些分子在某些情况下需要结合到表面，例如光纤。31，32分析生物化学家、临床和医学科学家以及细胞生物学家更喜欢在显微镜下使用自由移动的传感器分子群体，33，34尽管光纤工作现在也是可能的。另一方面，信息技术人员希望借助光子扫描隧道显微镜37或近场扫描光学显微镜在单分子水平上处理光开关。38，38a单个分子及其轨道的真实性不再受到怀疑。39
The crucial recognition events of chemistry, biology, and materials science occur in a much smaller world than the one we are accustomed to. Information about these events can be conveniently transmitted to us via light signals emitted by purpose-built molecular devices. 1r8 Besides this sensory role, 9r30 such molecular devices also have potential for information processing since their emission can be switched between two distinguishable states by environmental stimuli. In this review, we highlight the uniqueness and utility of such systems. It is remarkable that these devices serve several categories of beneficiary with very different needs and methods. Analytical chemists and environmental scientists usually require populations of sensor molecules which need to be bound to surfaces such as optical fibers in some instances. 31, 32 Analytical biochemists, clinical and medical scientists as well as cell biologists prefer to work with populations of freely mobile sensor molecules under a microscope, 33, 34 although fiber optic work is also possible now. 35, 36 On the other hand, information technologists would wish to deal with optical switches at the single molecule level with the help of photon scanning tunneling microscopy37 or near-field scanning optical microscopy. 38, 38a The reality of individual molecules and their orbitals is no longer in doubt. 39