GROWTH-ASSOCIATED PROTEIN GAP-43 IS EXPRESSED SELECTIVELY IN ASSOCIATIVE REGIONS OF THE ADULT HUMAN-BRAIN
GROWTH-ASSOCIATED PROTEIN GAP-43 IS EXPRESSED SELECTIVELY IN ASSOCIATIVE REGIONS OF THE ADULT HUMAN-BRAIN
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DOI：
10.1073/pnas.85.10.3638
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发表时间：
1988-05-01
影响因子：
11.1
通讯作者：
BENOWITZ, LI
中科院分区：
文献类型：
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作者：
NEVE, RL;FINCH, EA;BENOWITZ, LI
GAP-43是一种神经元特异性磷蛋白，与突触关系的发育和功能调节有关。研究人员利用人类GAP-43基因的cdna揭示了在新皮质的许多整合区域中，GAP-43 mRNA的总体水平较高，但在涉及感觉信息初始处理的皮质区域、几个脑干结构和尾状壳核中，GAP-43 mRNA的水平较低。原位杂交发现，表达GAP-43 mRNA水平最高的神经元集中在联合皮层第2层和海马锥体细胞中。对照研究表明，尽管编码阿尔茨海默淀粉样蛋白前体的mRNA，但其他一些rna的区域分布与GAP-43不同。蛋白质也有类似的表达模式。这些结果表明，皮质和海马神经元的一个有限子集可能专门用于突触重塑，并可能在人脑的信息存储中发挥作用。
GAP-43 is a neuron-specific phosphoprotein that has been linked with the development and functional modulation of synaptic relationships. cDNAs for the human GAP-43 gene were used to reveal high overall levels of GAP-43 mRNA in a number of integrative areas of the neocortex, but low levels in cortical areas involved in the initial processing of sensory information, in several brainstem structures, and in caudate-putamen. Neurons expressing highest levels of GAP-43 mRNA were found by in situ hybridization to be concentrated in layer 2 of association cortex and in hippocampal pyramidal cells. Control studies showed that several other RNAs had regional distributions that were different from GAP-43, although the mRNA encoding the precursor of the Alzheimer amyloid .beta. protein followed a similar pattern of expression. These results suggest that a restricted subset of cortical and hippocampal neurons may be specialized for synaptic remodeling and might play a role in information storge in the human brain.