Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge:: Role of SIV-specific CD8+ T cell responses
Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge:: Role of SIV-specific CD8+ T cell responses
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DOI：
10.1016/j.virol.2006.05.012
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发表时间：
2006-09-15
期刊：
影响因子：
3.7
通讯作者：
Robert-Guroff, Marjorie
中科院分区：
文献类型：
--
作者：
Malkevitch, Nina V.;Patterson, L. Jean;Robert-Guroff, Marjorie
以前，用可复制的腺病毒-SIV多基因疫苗引发并用包膜亚单位加强免疫，强烈保护了39%的恒河猴免受直肠SIVmac 251攻击。为了评估保护持久性，用SIVmac 251直肠再攻击11只受保护的和2只控制病毒血症的SIV感染的未免疫猕猴。在8/11名疫苗接种者中观察到强保护，包括两名表现出< 50 SIV RNA拷贝。在其他三个组中观察到与未处理对照组相比病毒血症减少。SIV感染的未免疫的猕猴适度控制了病毒血症，但表现出CD 4计数
Previously, priming with replication-competent adenovirus-SIV multigenic vaccines and boosting with envelope subunits strongly protected 39% of rhesus macaques against rectal SIVmac251 challenge. To evaluate protection durability, eleven of the protected and two SIV-infected unimmunized macaques that controlled viremia were re-challenged rectally with SIVmac251. Strong protection was observed in 8/11 vaccinees, including two exhibiting < 50 SIV RNA copies. Decreased viremia compared to naive controls was observed in the other three. The SIV-infected unimmunized macaques modestly controlled viremia but exhibited CD4 counts