Osteogenesis imperfecta: a genetic, radiological, and epidemiological study
Osteogenesis imperfecta: a genetic, radiological, and epidemiological study
复制标题
成骨不全症：遗传、放射学和流行病学研究
作者：
P. Andersen;M. Hauge
通过系统检索所有出生1.1岁的儿童，估计出生时骨生成障碍的点患病率。1970年至31年十二. 1983年在菲恩县（丹麦）。此外，人口患病率为31。十二. 1983年确定了该县所有成骨不全症患者。该县是丹麦的一个定义明确、具有代表性的次区域，人口统计学上包括约9%的丹麦人口。总之，这项研究发现了48例成骨不全患者。其中，17名患者出生时为1.1。1970年至31年十二. 1983年，12例为I型，2例为II型，2例为III型，1例为IV型。因此，出生时的点患病率为21.8/10万，人口患病率为10.6/10万居民。各型之间临床表现差异较大。
The point prevalence at birth of osteogenesis imperfecta was estimated by a systematic search of all children born 1.1. 1970 to 31. XII. 1983 in the county of Fyn (Denmark). Additionally, the population prevalence on 31. XII. 1983 of all patients with osteogenesis imperfecta in this county was determined. The county is a well‐defined, representative subregion of Denmark which demographically comprises a cross‐section including about 9% of the Danish population. Altogether, the study disclosed 48 patients with osteogenesis imperfecta. Of these, 17 patients were born 1.1. 1970 to 31. XII. 1983 and 12 had type I, 2 had type II, 2 had type III, and 1 had type IV. Thus, the point prevalence at birth was 21.8/‐100 000 and the population prevalence was 10.6/100 000 inhabitans. There was great variation in the clinical manifestations within and between the types.
影响因子：
4.2
作者：
Sillence,D
通讯作者：
Sillence,D
胶原蛋白生物化学的概念：胶原病是成骨不全症的基础的证据。
影响因子：
4.2
作者：
Eyre,DR
通讯作者：
Eyre,DR