Metabolism and oxidative stress response pathways in kidney cancer: a tale of chance and necessity.
Metabolism and oxidative stress response pathways in kidney cancer: a tale of chance and necessity.
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DOI：
10.14694/edbook_am.2015.35.220
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发表时间：
2015-01-01
期刊：
影响因子：
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通讯作者：
Linehan, W Marston
中科院分区：
文献类型：
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作者：
Sourbier, Carole;Srinivasan, Ramaprasad;Linehan, W Marston
2014年，全球有超过27万名肾癌患者，其中12万人死于这种疾病。在过去的几十年里，我们对这些肿瘤生长的遗传和分子机制的理解取得了重要进展，这导致了患者护理的改善。最近一些最重要的进展来自于生物信息学（基因组学、蛋白质组学等）产生的越来越多的大型数据集，以及它们的整合，以表征负责肾肿瘤发展和生存的遗传和分子因素。有趣的是，代谢失调和氧化应激途径在晚期肾肿瘤中普遍存在，是开发治疗方法时需要考虑和潜在靶向的重要因素。
Over 270,000 patients are affected with kidney cancer worldwide and 120,000 died from this disease in 2014. Over the last few decades, important progress has been made in our understanding of the genetic and molecular mechanisms underlying the growth of these tumors, which has led to improvement in patient care. Some of the most significant recent advances came from the increasing number of large datasets generated by bioinformatics (genomics, proteomics, etc.) and their integration to characterize the genetic and molecular factors responsible for kidney tumor development and survival. Interestingly, deregulated metabolism and oxidative stress pathways are commonly found in advanced-stage kidney tumors and are important factors to consider and potentially target when developing therapeutic approaches.