Biomimetic amplification of nanoparticle homing to tumors
Biomimetic amplification of nanoparticle homing to tumors
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DOI：
10.1073/pnas.0610298104
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发表时间：
2007-01-16
影响因子：
11.1
通讯作者：
Ruoslahti, Erkki
中科院分区：
文献类型：
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作者：
Simberg, Dmitri;Duza, Tasmia;Ruoslahti, Erkki
基于纳米颗粒的诊断和治疗具有很大的前景，因为可以将多种功能构建到颗粒中。其中一个功能是归巢到身体特定部位的能力。我们在这里描述的仿生颗粒不仅可以归巢到肿瘤，而且还可以放大它们自己的归巢。该系统基于一种肽，该肽识别凝结的血浆蛋白并选择性地归巢于肿瘤，在那里它结合到血管壁和肿瘤基质。涂有这种肿瘤归巢肽的氧化铁纳米颗粒和脂质体在肿瘤血管中积累，在那里它们诱导额外的局部凝血，从而为更多的颗粒产生新的结合位点。该系统模拟血小板，血小板也可以自由循环，但在患病部位积聚，并放大其在该部位的积聚。自放大归巢是纳米粒子的一种新功能。基于凝结的扩增大大增强了肿瘤成像，并且设想向颗粒添加药物载体功能。
Nanoparticle-based diagnostics and therapeutics hold great promise because multiple functions can be built into the particles. One such function is an ability to home to specific sites in the body. We describe here biomimetic particles that not only home to tumors, but also amplify their own homing. The system is based on a peptide that recognizes clotted plasma proteins and selectively homes to tumors, where it binds to vessel walls and tumor stroma. Iron oxide nanoparticles and liposomes coated with this tumor-homing peptide accumulate in tumor vessels, where they induce additional local clotting, thereby producing new binding sites for more particles. The system mimics platelets, which also circulate freely but accumulate at a diseased site and amplify their own accumulation at that site. The self-amplifying homing is a novel function for nanoparticles. The clotting-based amplification greatly enhances tumor imaging, and the addition of a drug carrier function to the particles is envisioned.